REVIEW noah Dan Stetson New frontiers in the cGAS-STING intracellular DNA-sensing pathway cell.com/immunity/pdf/S…

Congratulations to AAI President Akiko Iwasaki for being named one of Time's most influential people of 2024! Prof. Akiko Iwasaki TIME Yale Center for Infection and Immunity time.com/collection/100…

Our most complex biologic system—immunity—is reviewed in 3 new Cell papers, open-access Adaptive cell.com/cell/fulltext/… Innate cell.com/cell/fulltext/… New insights cell.com/cell/fulltext/… Ruslan Medzhitov

#Immunity30th Stetson, Dvorkin, Cambier & Volkman summarize recent insights into cGAS-STING biology and its role in host defense, immunopathologies, & anti-tumor immunity: "New frontiers in the cGAS-STING intracellular DNA-sensing pathway" authors.elsevier.com/a/1iuug3qNrUxt…

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi biorxiv.org/cgi/content/sh… #biorxiv_immuno

Congratulations Marcus Wong 黃子穎 on this wonderful study suggesting that host inflammatory responses to DENV NS1 may be protective as well as pathogenic. @russellevance Eva Harris dx.plos.org/10.1371/journa…

The final version of tyler billipp's graduate school work is now published! Tyler uncovered an epithelium-intrinsic response unit that couples tuft cell sensing of the lumen to Cl-/fluid secretion from neighboring enterocytes cell.com/immunity/fullt…

The balance between antiviral and antibacterial responses during M. Tuberculosis infection is regulated by the ubiquitin ligase CBL biorxiv.org/cgi/content/sh… #biorxiv_immuno

Mutagenesis screen of UNC93B1 reveals regulatory regions affecting TLR3, TLR7, and TLR9 responses that are marked by coding variants in autoimmune patients Journal of Experimental Medicine Olivia Majer The Barton Lab doi.org/10.1084/jem.20…

The findings by Victoria Rael, Julian Yano et al. The Barton Lab implicate the UNC93B1-TLR7/8 axis in human monogenic #autoimmunity and provide a functional resource to assess the impact of yet-to-be-reported UNC93B1 mutations. hubs.la/Q02yhHY00 #Lupus

Excited to share my postdoc work from the Gale lab! We asked where/what vRNAs are sensed during WNV infection. Turns out low levels of -vRNAs make their way into the cytoplasm during egress to be sensed by RIG-I and their accumulation underlies heterogeneous immune activation!

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity biorxiv.org/cgi/content/sh… #biorxiv_immuno

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

🚨New cGAMP transporter just dropped🚨 Check out the latest preprint from the lab, led by grad student Valentino implicating SLC7A1 as the dominant cGAMP transporter in T cells biorxiv.org/content/10.110…

Midwinter Conference of Immunologists is coming January 25-28, 2025! Check out the speakers and register on our new website: web.cvent.com/event/793d943e… Deadlines: Pre-conference URM travel award: 10/22 Early-bird: 11/15 Abstracts: 12/13

Happy to announce we are recruiting new faculty to join the Metabolism Department at Van Andel Institute (VAI). A great opportunity to join a dynamic community of scientists in West Michigan studying the metabolic underpinnings of health and disease. Apply here: vai.wd1.myworkdayjobs.com/en-US/VAICaree…

The latest from the Stetson lab! A new IFNb-reporter mouse to study type I IFN regulation. Check it out: journals.aai.org/jimmunol/artic…

Excited to share our new preprint on the Taxol pathway! We developed a strategy to systematically activate and identify gene sets in non-model organisms and used it to find 8 new genes in the Taxol pathway, allowing us to biosynthesize Taxol precursors de novo. Surprisingly, this

Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a Nature News & Views Elliott Bernard and Petr describe new results from Vishva Dixit and Ishan Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH