Today we report in Nature Medicine a study led by Christine & Jonathan Seidman’s lab in which we used adenine base editing in vivo to correct a common mutation that causes hypertrophic cardiomyopathy (HCM), a disease that occurs in ~1 in 500 people (1/8)

So, so cool. TEs to the rescue in naked mole rats. Precancerous cells proliferate to quickly for DNA methyltransferase to keep up, resulting in expression of retrotransposons, which triggers interferon response and cell death. nature.com/articles/s4159…

A huge congratulations to Liu group alumn Holly A. Rees on being named to this year's Forbes Under 30 for Science & Healthcare 🎉 *so* well deserved 🥂 forbes.com/profile/holly-…

"I continuously remind myself that no one is guaranteed an easy life, but we can make it easier for others." Read 2018 chemistry laureate Frances Arnold's inspiring and moving life story: bit.ly/3tjHmpU #NobelPrize

One of my favorite stories ever is finally out! Sitting next to Yan Hu and learning from him every day is a true privilage. PRINT is an example of how clever computation can reveal so many new layers of biology.

Grad student Dani Keahi studies the role of DNA repair in preventing medulloblastoma, the most common pediatric brain cancer. Her focus is on how developing brain cells are vulnerable to DNA damage and the pathways that protect them from becoming cancerous. #AAPIHeritageMonth

Congrats!! 🎉 Check out this genius Croatian PI opening her lab at NYU, she is hiring soon!

The development of a new strategy to reprogram the mammalian electron transport chain has earned Jessica Spinelli, PhD, a pair of honors: selection to the 2023 class of Searle Scholars and a Smith Family Foundation Biomedical Research award: umassmed.edu/news/news-arch… UMass Chan Medical School

Rockefeller's Agata Smogorzewska has been promoted to Professor with tenure. Congratulations, Agata Smogorzewska! Learn more about Agata's research on DNA repair mechanisms and how she got into this work: rockefeller.edu/news/34096-stu…

Next week I'll be starting my own lab at UCSF UCSFUrology! We’ll be using synthetic biology and functional genetic screens to understand antigen presentation and T-cell recognition in cancer and other diseases. We’d love for you to join us! More info at brunolabucsf.com

What an honor working with Isabel! Can’t wait to see what she does after launching her experiment to space 🪐☄️🚀👩‍🚀

Our PI is a genius!! Also the most supportive mentor and the kindest human.

Chroma out in Nature today! So glad to finally be able to share details of our experimental validation including x-ray crystallography with the world 💎 tl;dr, our generative model for protein design is working really well. Publicly available code, click through below!

We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!

Talk on new methods in single-cell epigenomics from Jason Buenrostro from Harvard University at #singlecellgenomicsday

It was truly an honor for Aleksandar Radakovic and me to host our mentor BogerLab during the Closs Lecture at UChicago Chemistry. Having our old mentor visit is akin to welcoming a cherished family member, leaving everyone in awe. Such moments in Grad school are rare and unforgettable.😊

TIME's list of the 100 Most Influential People in the world is out. I'm honored, delighted, and grateful to be a part of this incredible group #TIME100 🙏🏼🙏🏼🙏🏼 TIME time.com/6964230/akiko-…

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

This microscope can simultaneously sequence an individual cell’s DNA and pinpoint the location of its proteins with high resolution — all without having to crack the cell open and extract its contents go.nature.com/3Y5jqGG