Great work from Yang I Li and colleagues showing that splicing errors that are quickly degraded by NMD are remarkably common -- this affects around 15% of all nascent transcripts. This article really changed how I think about alternative splicing and noisy splicing.

I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…

Excited to be heading to DC for #ASHG2023! Interested in chromatinQTL calling and trans gene regulation? Check out the talk and posters from our group Lili Wang, Nikita Babushkin and Jinghui Li.

My poster is up at #ASHG23 at PB1083! If you are interested in scATAC QTL and how it expands our understanding of disease GWAS, hear me talk about it Saturday afternoon or just come and see wherever you have time!

My lab at The University of Chicago has an open postdoc position. AT #ASHG2023 AND interested in Statistical genetics and functional genomics? Please reach out and let's chat!

Yang I Li Summary statistics are now available on Zenodo: zenodo.org/records/103544…, and future links will be added to the portal: intervalrna.org.uk/downloads/

We're ready for #PAG31! Justin Duplantis is all set up at Booth 429 in the exhibit hall for the International Plant and Animal Genome Conference in San Diego. Come by through Tuesday the 16th to chat about your #bioinformatics needs and pick up some swag!

Excited to share our review paper in Cell! With Sasha Gusev Sohini Ramachandran Yang I Li we discuss the genetic and molecular architecture of human traits, future opportunities and challenges and ways forward. authors.elsevier.com/a/1igrbL7PXqPfU

My lab is looking for postdocs excited about questions in population, evolutionary and quantitative genetics. Please reach out; informal inquiries most welcome. I was not able to attend #TAGC24 / #PEQG24 myself, but some stellar colleagues are there to chat about our work:

Our work led by Lili Wang on identifying trans genetic effects of gene networks is out in Cell Genomics today!

🎉Congratulations to the 2024 #CZBiohubCHI Investigators! The cohort of 48 of Chicago’s most creative and accomplished scientists and engineers will use multidisciplinary approaches to understand inflammation and the dysregulation of immune cells.

Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome Nature Genetics Yang I Li nature.com/articles/s4158…

We’re thrilled to announce the publication of SpliceVarDB: A comprehensive database of experimentally validated human splicing variants in AJHG 🧬 📖 cell.com/ajhg/fulltext/… #splicing #GeneChat

Very useful resource for validating methods for predicting mutational effects on splicing. Looking forward to using this in our next project!