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Three papers in one week from the many teams in the lab! very exciting. cell.com/cell-stem-cell… cell.com/cell/fulltext/… genomebiology.biomedcentral.com/articles/10.11…

Super Excited to share our new pre-print describing the first atlas of human 3'QTLs, i.e. ~0.4 million genetic variants associated with APA of target genes across 46 #GTEx tissues. Fanglue Peng Eric J Wagner Wei Li biorxiv.org/content/10.110…

Our cancer driver gene prediction paper is finally online. advances.sciencemag.org/content/6/46/e…

Super excited to share our recent work on 3′UTR alternative polyadenylation (APA) quantitative trait loci (3′aQTLs), which can explain ~16.1% GWAS SNPs and are largely distinct from eQTLs. Wonderful collaborations with Eric J Wagner Lei Li nature.com/articles/s4158…

Nested epistasis enhancer networks for robust genome regulation science.org/doi/10.1126/sc… This research between our lab, Keji Zhao (NIH), Wing Wong (Stanford), reveals an epistasis enhancer network for gene expression robustness, and predicting non-coding genome in disease risk.

Very excited to share SELMA, a computational method we developed for ATAC-seq & DNase-seq bias estimation, recently published in Nature Communications spearheaded by Shengen Shawn Hu w input from Cliff Meyer Lin Liu @guertinlab Ke Deng & Tingting Zhang nature.com/articles/s4146…

Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)

We're excited to introduce GAGE-seq, a single-cell co-assay for 3D genome (#scHiC) & transcriptome (#scRNA). We revealed 3D genome--gene expression interplay in mouse cortex (even integrated w/ #spatialtranscriptome) & during human hematopoiesis. Preprint: biorxiv.org/content/10.110…

@bqdx 吃货就是花哨

@bqdx 真笨！

Excited to share our new research! We're using ultrasound for precise control in gene regulation & base editing—both in cells and living animals. A fantastic collaboration with Dr. Katherine Ferrara, led by Dr. Pei Liu. Learn more: nature.com/articles/s4146…

Really cool technology - consortium-wide mapping of protein-DNA interactions! 👍

Thrilled to share our UCI TR-gnomAD published in Cell today: cell.com/cell/fulltext/…. UCI TR-gnomAD is the first biobank-scale genetic reference for ~1.0M Tandem Repeat (TR) expansions across 340K humans, facilitating TR-based disease association studies and clinical diagnostics

Thrilled to share our TR-gnomAD published in Cell Cell Press today! TR-gnomAD is the first biobank-scale genetic reference for ~1.0M Tandem Repeat expansions across 340K humans, facilitating TR-based disease association studies and clinical diagnostics. Wei Li

Very excited to have Mellon out in Nature Methods today!

Xueqiu Lin, Wei Li and colleagues find that undermethylated CpGs are associated with chromatin loops genomebiology.biomedcentral.com/articles/10.11…