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Last year, we welcomed Andre Nussenzweig (andre nussenzweig lab, National Cancer Institute) for a Birnstiel Lecture - apologies for the delay, here is the long awaited recording of "Neuronal Genome Stability and Plasticity": 📺youtu.be/s9vd6tbgSXc

Check out this excellent opportunity using sequencing strategies to study genome integrity: replication, repair, genome organization and more.

Congrats! Great pics!

Huge congrats to Andre, Rapahel, Vennu and the others!

The Cortez lab (lab.vanderbilt.edu/cortez-lab/) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.

With their help, we found formulations of engineered nanoparticles that can efficiently deliver Cas9 into (iPSC-derived) postmitotic human neurons. And cut open their DNA. @JiaChen98369353 from andre nussenzweig lab lab took pictures of these Cas9-induced breaks in our neurons’ DNA.

Great collaboration with Giordano Reginato and Cejka Lab is now online at Nature Communications. Their findings that nickase Cas9H840A is removed from DNA by HLTF really helped us in our fork collapse story. nature.com/articles/s4146…

Now online! 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming dlvr.it/TCfNJg

I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin Matt Franklin (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.110…

huge congrats!

amazing

Very excited to be involved in this study: HDAC6 sensors valine deprivation and moves to nucleus->actives TET2->TDG dependent DNA damage. Huge congrats to Dr. Ping Wang and the team, also to my talent postdoc Shuheng Wu who joined as a co-first author. nature.com/articles/s4158…

Online Now: Repair of replication-dependent double-strand breaks differs between the leading and lagging strands dlvr.it/TGYr69

Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS. Kathleen Helen Burns Jennifer Ann Karlow biorxiv.org/content/10.110…

Delighted to share this beautiful story of collaboration with Lu's and ZZ's groups! Thank you for introducing me to the fascinating world of transposon elements.

Learn how homology search might work in 3D genome! We combine very fast CRISPR and Hi C to look at 3D genome changes during DNA repair and found that break anchored DNA extrusion by cohesin can help search for homologous sequences.

We're incredibly excited to share our new method, Paired-Damage-seq, out Nature Methods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). nature.com/articles/s4159…

Happening Now in the Skyline Ballroom: Andre Nussenzweig is presenting his lecture, "Maintaining genome stability." asbmb.org/asbmb-today/pe… #ASBMB25

Our amazing group for #Recombination25! It’s been an fantastic few days of science, networking, and collaborations🥳 Lets celebrate in style at tonight’s gala dinner! 🎉💃

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank Chaolin Zhang Hachung Chung at Columbia University Lena Steckelberg More to come nature.com/articles/s4158…