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Our structures of the #cardiac #sarcomere are now published in nature! With #teamtomo at Stefan Raunser lab, we've used #CryoET to unveil how #myosin and #actin filaments arrange in #muscle relaxed with #mavacamten. Great collaboration with Gautel Lab! doi.org/10.1038/s41586… 🧵

The University of Massachusetts Padron-Craig lab #Cryo-EM paper (Dutta et al.) back-to-back with Raunser lab #Cryo-ET (Tamborrini et al.): an example of complementarity and reproducibility of these #EM techniques. Dutta et al shorturl.at/mwU16 Tamborrini et al shorturl.at/itvB6

Here w/ The Arany lab we reveal another piece of the puzzle of how #titin mutations cause DCM! Quentin shows (in patient 💔) that truncated titin is made, incorporates into the sarcomere and bears load upon stretch… but not as well as full length titin! tinyurl.com/3uu6cfhe

Really proud to share our last preprint on Omecamtiv and Mavacamten, two modulators of cardiac myosin. Years in the making. Very happy to work with the team, especially Anne, Carlos, Daniel & Stéphane on this paper. biorxiv.org/content/10.110…

Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflamm... sciencedirect.com/science/articl… Congratulations on this JACC scientific statement Monica Mukherjee MD, MPH and Brittany Weber and coauthors! JHHecho Johns Hopkins Ciccarone Center Johns Hopkins Cardiology

We are excited to share our work on #RV function in #LVAD patients. Using RV P-V loops, we find occult RV contractile dysfunction in LVAD patients (vs controls), which correlates to the loss of septal contractility from LV unloading. doi.org/10.1016/j.heal…

Myofibril relaxation kinetics vary among HFpEF models, implying unique sarcomeric contributions to diastolic dysfunction. #AHAJournals #ResearchLetter Johns Hopkins Cardiology ahajrnls.org/3SmHwLs

Nelson et al. show that myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle. hubs.la/Q02jVFVQ0 From our #Biophysics collection: hubs.la/Q02jVNjw0 #BPS2024

📢 Interested in bench - bedside - back #FunctionNotFailure 🫀 research, cardiac metabolism, glycobiology and clinical proteomics 🧪🔬?? My lab Johns Hopkins Cardiology is looking for a talented T-32 post-doc to join us! Visit hopkinsmedicine.org/heart_vascular… and msg if interested! 🙏 re-post!

Really excited to announce our work using controlled MyBP-C cleavage in skeletal muscle is now published open access in Nature Communications! Samantha Harris and I agreed to this collab in September 2022 and now complete! Ask any Qs in the comments! 👨‍🔬👩‍🔬🔬💪 nature.com/articles/s4146…

Very glad to share the most recent publication from the ⁦MuscleX_Lab⁩ at ⁦⁦Journal of Physiology⁩ to show that fast skeletal muscle is optimized for rapid contractions, and the slow cardiac muscle is more finely tuned to allow for the cardiac reserve physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Please join us for our next ECC virtual seminar.! When: Jun 7, 2024 01:00 PM Eastern Time (US and Canada) Register in advance for this meeting: fsu.zoom.us/meeting/regist… After registering, you will receive a confirmation email containing information about joining the meeting.

We are pleased to share this new work in ERJ on RV diastolic reserve in PAH (assessed by P-V loops): High exercise afterload blunts CO reserve in PAH by severely worsening RV stiffness and LV filling. erj.ersjournals.com/content/early/…

Excited to help Alex Lewalle and Cardiac Electro-Mechanics Research Group with this paper which suggests that using an SRX to DRX transition accelerated by force is a good way to simulate myocardial mechanics. Lots of mechanistic questions left :-) sciencedirect.com/science/articl…

Grateful to NIH NHLBI and our team of investigators for my first R01 award! Special thanks to my amazing mentors @dkassjhu & Ryan J Tedford MD for all their guidance. Over the next 5 yrs we hope to uncover the best clinical indices of myocyte dysfunction in RV failure due to PH/HF

HFpEF myocardium displays a robust reduction in proximal glycolytic, HBP, PPP metabolites and enzymes. Importantly, this profile persisted after adjustment for BMI, DM, age, and sex. Read the full article here: bit.ly/4cAlM5X @dkassjhu Johns Hopkins Cardiology

Very nice to see the work between MuscleX_Lab at Illinois Tech and RegnierLab F Moussavi-Harami, MD at University of Washington finally published in Journal of General Physiology. It has been a very long and productive collaboration and more papers in the making!!!

Thick filament structural changes in the presence of calcium. From Saffie Mohran, Weikang Ma & colleagues MuscleX_Lab Illinois Tech showing that calcium has a direct effect on thick filament activation in porcine myocardium: hubs.la/Q02QLtSp0 #Myofilaments #CardiacMuscle

Not that this ever happens 😏, but what if you can’t get good PCWPs during invasive exercise RHC? Lean instead on Ex PAC & RAPs to distinguish pre- & post-cap disease. Kudos to ⭐️ ⁦The Osler Medical Residency⁩ Dr. Maggie Montovano for this great work! pmc.ncbi.nlm.nih.gov/articles/PMC11…

Very productive run at Cornell High Energy Synchrotron Source with Vivek Jani and Marcus. We collect patterns from human heart tissue (HFpEF, HFrEF, HCM, SVD) probably for the first time ever there, and more patterns from animal hearts. Looking forward to come back soon!!!