1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)

Nice therapeutic success ! Successful coil occlusion of intracranial aneurysm in a child with STAT3 hyper IgE syndrome rupress.org/jhi/article/1/…

Successful coil occlusion of intracranial aneurysm in a child with STAT3 hyper IgE syndrome. New study from Archan Sil, Pandiarajan Vignesh and colleagues (PGIMER, Chandigarh, India): hubs.la/Q03qGvKC0 #InbornErrorsOfImmunity

This review by Don Vinh highlights the diversity in intrinsic fungal susceptibility across individuals and populations, through genetic- and autoantibody-mediated processes. hubs.la/Q03kDJ-v0 📘 In our Clinical #Immunology Collection: hubs.la/Q03kFj_p0 #FOCIS2025

Super excited about our recent paper describing a high throughput screen for functional variants in the context of APDS. Rare disease ain’t always that rare! Great collaboration with Ben Izar and Dusan Bogunovic! cell.com/cell/abstract/…

Inhibition of lysosomal degradation increases ADA2 expression. Congrats ⁦⁦⁦⁦Lisa Ehlers⁩ and the rest of my team and all contributors. Thank you ⁦FWO⁩ ⁦European Research Council (ERC)⁩ for the support. pubmed.ncbi.nlm.nih.gov/40545182/

A must-read for anyone interested in human B lymphocytes, their physiology and pathology !

➡️Whole-genome sequencing of 2,762 Indians has unravelled the layers of ancestry, high intermixing with Neanderthals and Denisovans. This along with high endogamy in India could potentially result in harmful mutations in some groups. sciencechronicle.in/2025/06/28/a-g…

ICYMI: Our Clinical #Immunology Collection feattures recent and exciting advances in the field of translational immunology – novel discoveries in #autoimmunity, tumor immunology, ocular- and #neuroinflammation, #immunodeficiency & human disease genetics 👉 hubs.la/Q03kK8480

Impact of BFM90 based CT on immune reconstitution Check out our full article published in IJHBT 👉🏻 link.springer.com/article/10.100… For full pdf rdcu.be/eufiZ 🧬 Key Findings: •📉 B-cell depletion: >35% had undetectable B cells by maintenance; suppression persisted

Prompt diagnosis of severe combined immunodeficiency is critical. A study explores variable factors including the impact of newborn screening associated with hematopoietic stem cell transplantation outcomes and overall survival in a multiethnic cohort. bit.ly/4402HJ4

Journal of Human Immunity's July issue is here! hubs.la/Q03vJ9Qp0 The cover image shows MHC class I–mediated antigen processing and presentation. From Gadolae et al. (hubs.la/Q03vJcff0) reviewing #InbornErrorsOfImmunity affecting the MHC class I pathway for antigen presentation.

Every dollar invested in #primaryhealthcare yields up to 10$ in economic growth. Expenditure on health (especially public health & primary care) must be seen as an investment and not a spend.

Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients rupress.org/jhi/article/1/…

A fascinating Review about inborn errors of immunity in Rheumatology !

Here’s the latest from Hsieh Lab! Can we link tissue-specific spatially resolved immune molecular, cellular, and histopathology profiles to specific immune pathway defects? From biopsy to precision medicine? #theissueisinthetissue doi.org/10.1002/art.43…

Staines-Boone, Blancas-Galicia, and colleagues characterize a new genetic predisposition to coccidiodomycosis. Autosomal dominant STAT1 deficiency is a monogenic defect that increases susceptibility to coccidioidomycosis in humans. hubs.la/Q03zlsqz0 #InbornErrorsOfImmunity

STAT1-GOF is characterized by infections & #autoimmunity. In Journal of Human Immunity, Buddingh, Schuetz et al. report overall survival after allogeneic #HSCT in an international cohort of 36 patients is 72.2%, markedly improved from an earlier report. hubs.la/Q03zBrMb0

New in Journal of Experimental Medicine: Fu et al. identify biallelic germline ASXL1 variants as the cause of a novel #InbornErrorOfImmunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, & malignancy hubs.la/Q03zN5pk0

New Perspective article from Timothy Buckey, MD, MBE and Jennifer Heimall Children's Hospital describes the #ethical #dilemmas encountered by #clinical #immunologists in the evaluation of an inborn error of immunity. hubs.la/Q03BNtN40 #InbornErrorsOfImmunity