The latest work from our lab, led by Matt Ginley with help from Julia Carleton and A Cristina Rodriguez, Ph.D., is up on BioRxiv. We asked whether recruiting CRISPRa fusions to enhancer combinations can replace estrogen receptor alpha in terms of activating gene expression. SPOILER ALERT..they can 1/

Our review on estrogen signaling and endometrial cancer is out. Led by A Cristina Rodriguez, Ph.D. and Zannel Blanchard, PhD it discusses clinical importance of estrogens and the known/unknown molecular details. It also throws a little shade at funding agencies for lack of endo ca $. link.springer.com/article/10.100…

Great sciencing by A Cristina Rodriguez, Ph.D.! Definitely worth a read or three🧬🧪🧫

Our paper on the molecular characterization of mutant estrogen receptor alpha in endometrial cancer was published today in Genome Research! Big congrats to Zannel Blanchard, PhD on her incredible effort as 1st author! genome.cshlp.org/content/29/9/1…

My article on using synthetic activators to study enhancers is now out! Thank you to everyone who made this work possible!!

Finally got a publication mug! Hoping the XL size will help me get more work done. Thanks, Jay Gertz! #mugshots #AcademicTwitter

Our latest work is out Genome Research. Led by Jeff Vahrenkamp, we developed a technique called FFPEcap-seq that can sequence 5' ends of highly degraded formalin-fixed paraffin-embedded RNA. Thanks to National Cancer Institute IMAT program for the support! genome.cshlp.org/content/29/11/…

Thanks Huntsman Cancer Institute for the great write up and fun photoshoot!

Awesome work by Julia Carleton!

The latest Gertz lab "stay at home" preprint is out. Led by Spencer Arnesen, with Zannel Blanchard, PhD, Vaciry, Dr. Steffi Oesterreich, and JenRicher, we focus on estrogen receptor mutations in breast cancer and ask the question: why do ER mutations cause unexpected gene expression changes? Thread

I'm a little late in tweeting about this, but Julia Carleton's paper on enhancer regulatory sharing is out in peer reviewed form. Thank you @NAR_Open and reviewers for the thoughtful evaluation and suggestions! academic.oup.com/nar/advance-ar…

Excited to share my journey and give my perspective on being Black in Academia. Thank you SACNAS for this opportunity!

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Soooo......this PhD thing is really happening! October 21st, 3pm Mtn Time. 😱😁 #orgulloboricua #bitofaday (DM for Zoom details if interested in watching. )

Excited to share that our first study on ER mutations and gene regulation in breast cancer, led by terrific work from Spencer Arnesen, is out in Cancer Research! It was a great collaboration with JenRicher, watch for our companion paper, and Dr. Steffi Oesterreich

The latest Jay Gertz preprint was just posted. It was a great group effort led by Matt Ginley with help from Xiaoyang Zhang lab and John Lis’ lab. In this study, we explored how regulatory elements influence gene expression timing and noise in response to estrogen 1/

Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by Zannel Blanchard, PhD and Jay Gertz, have identified potential new treatment options for people with endometrial cancer. bit.ly/47GqKwn

Thanks Jay and all the incredible people who made this happen!