Congratulations to the trialists to perform such a large clinical trial! How do we interpret the results in the era of PSMA-PET imaging?

Current Issue: Association Between Local Radiation Therapy to the Primary Bladder Tumor and Overall Survival for Patients with Metastatic Urothelial Cancer Receiving Systemic Chemotherapy buff.ly/3wGFXvP #localradiation #bladdertumour #medtwitter #urology #oncology

Is the Phoenix criteria after primary radiotherapy still valid in PSMA-PET times? >50% mets in pts with PSA<2, almost all lesions salvageable! #Radonc Vedang Murthy ➡️sciencedirect.com/science/articl… ➡️ euoncology.europeanurology.com/article/S2588-…

Mudit Chowdhary, MD Sean Collins Prostate SBRT @ USF Health OncoAlert Daniel E Spratt Rahul Tendulkar, MD Sean McBride @ParikhSimul Jacob Witt, MD DocDaviesMD Jason Beckta @SouMyajiT_RO Giving a cost expensive systemic therapy for a localized and curable disease and observing grade 3 tox. I would like to know how to explain this concept to the patients..

Very comparable results were shown years ago with 5α-reductase inhibitors, e.g. in REDEEM trial   sciencedirect.com/science/articl…   Several advantages of deferred treatment are gone when patients with low risk prostate cancer get a drug like enzalutamide.

In a patient with PSMA-positive oligometastatic #prostatecancer, planned for metastases directed therapy: ➡️ What might be reasons to perform radical prostatectomy instead of radiotherapy to the prostate? ➡️ Do you know any decision tool already published? #radonc

The future is already here! NRG GU009..Felix Feng at EAU_

Is a PSMA- PET CT part of the baseline staging in this clinical trial?

PET-guided salvage RT will allow long term survival in this case! But primary radiotherapy would have same long term results! 😔

Wow wow wow: survival benefit for TMT! What about QOL? May be we should compare data from UK and Germany in a similar way?

ESTRO consensus for RT in the management of oligom PCa: - PSMA PET✅ - MDRT for patients diagnosed with up to 5 lesions in all disease settings - Systemic therapy + RT probably more efficient - Not switch systemic treatment in the mCRPC setting sciencedirect.com/science/articl…!

Dear Michael: Happy Birthday! We, from Dresden Nationales Centrum für Tumorerkrankungen Dresden and Oncoray thank you a lot for the great party in Heidelberg, Michael Baumann, MD!

Perhaps we will compensate our travel to #ESTRO23 by applying some hypofractionation in few of our patients 😉

Constantinos Zamboglou Sophia Kamran, MD Only 46 pc PFS at 3 years with salvage RT and 6m ADT? 🤔 🤔 What am I missing? PSMA-PET of course!

Development and validation of a multi-institutional nomogram of outcomes for PSMA-PET–based salvage radiotherapy in recurrent #ProstateCancer. Presentaton by Constantinos Zamboglou Uniklinik Freiburg. ASCO #GU23 written coverage by Christopher Wallis (he/him/his) University of Toronto > bit.ly/40ZpAJd

Are there any data or publications showing benefit for such a brave procedure? Remember , some years ago the surgeons failed to remove the seminal vesicles properly!

Interesting data - probably retrospective. Let’s wait for the full publication!

Constantinos Zamboglou Dr Srinivas Chilukuri Not close at all. We are working on generating some evidence for the need to boost, hence asked! 😀

Is it just me, or are others less inclined to use Twitter following the logo change? Somehow, now feels very different. If folks aren’t using Twitter as much, what are you using?

Really important and been saying this for many years so good to see other sources supporting. Extent of debulking prognostic but not therapeutic nor practiced in other cancers. Pts in BC2001 with biopsy only did no differently to those with resections