A script to define optimal directions in multishell diffusion MRI and prepare files for different scanners. brainder.org/2025/05/05/156…

Excited to have 4 posters from our lab at #OHBM2025! 📅 June 25 (1:15–3:15 PM) & June 26 (1:45–3:45 PM) ⬇️ Meet our presenters and their work below!

Thrilled to finally share a huge piece of my PhD project! Our paper “The Topological Architecture of Brain Identity” is now out on bioRxiv: biorxiv.org/content/10.110… 🧵 1/n

Polygenic risk for transdiagnostic psychopathology was linked to overall psychopathology and heritable brain network topography during early adolescence. ja.ma/44aX3mc

Visit me at poster 1497 on longitudinal normative modelling at #OHBM2025 :)

Cortical myelin is ⬆️ in association cortices of antipsychotic-naïve, 1st-episode psychosis patients vs healthy controls, suggesting that abnormal gray matter myelination may disrupt cortical circuits in schizophrenia-spectrum disorders nature.com/articles/s4138…

Microsoft claims their new AI framework diagnoses 4x better than doctors. I'm a medical doctor and I actually read the paper. Here's my perspective on why this is both impressive AND misleading ... 🧵

Bootstrapping and simple simulations reveal that consistent (i.e,. cross-site correlations of r>0.5) effects can be observed for schizophrenia with sample sizes >150, but much larger samples may be needed for other disorders, consistent with a low SNR of the disease phenotype

Ever wondered if we could see what someone is looking at just from their brain signals? In this talk, Dr.Zhang Yichi from our lab will reveal how to use AI to reconstruct images & videos directly from brain! 📍Jurong Regional Library, Programme Zone ⏰2:30-3:30 pm,12 July

A new study from the lab Nature Medicine Over 6,000 proteins, more than 10,500 individuals. #Alzheimers, #Parkinsons, and #FTD. Muhammad Ali maps the shared and disease-specific plasma proteomic landscape of neurodegeneration WashU Medicine Neurology nature.com/articles/s4159…

1/11 Excited to share our @Naturestudy led by Leon Ooi Csaba Orban Shaoshi Zhang doi.org/10.1038/s41586… It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...

On behalf of the CNV analysis workgroup of the PGC Consortium I'm pleased to share our latest paper "Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects" 🧵1/N medrxiv.org/content/10.110…

The magnet is always on

Happy to share that our article “Dissecting human cortical similarity networks across the lifespan” is now published online at Neuron Neuron. led by Xinyuan Liang and Lianglong Sun cell.com/neuron/abstrac…

The #FiberDataHub is approaching 50,000 ready-to-use datasets and now has a citable reference: nature.com/articles/s4159… Though often used with #DSIStudio, the hub is an independent resource that can be accessed using Python and used by DIPY, MRtrix and other tools!

Through comprehensive proteomics, blood vessels were the organ first to show aging, of 13 organs assessed, in a cohort of 76 individuals aged 14 to 68 years, with an aging inflection around age 50 cell.com/cell/abstract/…

NetBat - a new method for harmonizing structural connectomes based on stochastic block models Seems to perform better than Com- and Cov-Bat when applied to connectivity matrices sciencedirect.com/science/articl…

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/journa… How does blood perfusion map onto canonical features of brain structure and function? Asa Farahani investigates PLOS Biology ⤵️

Depression often co-occurs with chronic illness, e.g. heart disease, diabetes and obesity, which may be explained by chronic inflammation & metabolic dysfunction. But, what is the course of immunometabolic dysfunction in depression and how that may relate to brain changes?🧵1/6

Epic work led by Habib Ganjgahi is out in Nature Medicine... data-driven clustering of MS finds 3 distinct states, early/mild, active, advanced, w/ transition to the advanced state only occuring through the active state... replicated twice! doi.org/10.1038/s41591…