From the April issue: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion brnw.ch/21wRRjh By Charles Ishak Sajid Marhon @DeCarvalho_Lab and colleagues University Health Network Princess Margaret Cancer Centre MD Anderson Cancer Center

Now online in Cancer Discovery: Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis - Benjamin Kahn, Ben Stanger, and colleagues doi.org/10.1158/2159-8… Penn Medicine Penn Medicine - Abramson Cancer Center

ALL AACR journal content is free to read during #AACR25, including this authoritative and timely review on ADCs!

Congratulations to Sandra Misale, PhD, recipient of the 2025 Cancer Discovery Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdp #AACR25 Johns Hopkins Medicine Johns Hopkins Kimmel Cancer Center AACR

Online now concurrent with the #AACR25 Opening Plenary, by plenary speaker Catherine Wu: The Future of Personalized Cancer Vaccines brnw.ch/21wSfIl

HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Vaccine Efficacy brnw.ch/21wSfK7 By #AACR25 @Pezcoller–AACR Award for Extraordinary Achievement in Cancer Research winner Douglas Hanahan

Online today concurrent with his #AACR25 award presentation!

Online now concurrent with the #AACR25 Major Symposium on Mechanisms Underlying Differences in Cancer Incidence, by speaker Jun Yu: Intrahepatic Microbial Heterogeneity in Multifocal HCC and Its Association with Host Genomic and Transcriptomic Alterations brnw.ch/21wSfMx

If you're at the #AACR25 Major Symposium on the Interplay between Immunology & Somatic Evolution, read the work in Cancer Discovery being presented by speaker Ronny Drapkin 🎗 on a precancer atlas of fallopian tube precursors to high-grade serous carcinoma doi.org/10.1158/2159-8…

Online now for the #AACR25 Late-Breaking Abstract Minisymposium: Mutant p53 Gain of Function: Why Many See It, Why some Don’t brnw.ch/21wSfUt A perspective by Gigi Lozano, PhD, Carol Prives, and Kanaga Sabapathy

Online now for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer brnw.ch/21wSgTw

Online now concurrent with the #AACR25 oral presentation by Cancer Discovery Early Career Award Winner Sandra Misale: Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations brnw.ch/21wSh8j

Online now concurrent with the #AACR25 Major Symposium on #Immunometabolism by session speaker HoLab: PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Anti-Tumor Immunity against Liver Cancer and Liver Metastasis brnw.ch/21wSheD

Author Ping Chih-Ho presents at #AACR25. Read his article, published today: PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis brnw.ch/21wShlm

Join us starting soon! ➡️Learn about manuscript submission and review. Cancer Discovery AACR #AACR25

Online now concurrent with Victor Velculescu's #AACR25 presentation on next-gen liquid biopsies for early detection: Detection of Brain Cancer Using Genome-Wide Cell-Free DNA Fragmentomes by Dimitrios Mathios, Noushin Niknafs, Victor Velculescu, et al. WashU Med Taylor Family Department of Neurosurgery AACR

The May issue of Cancer Discovery is now online! The cover features work by Carlota Arenillas, ToledoLab_VHIO, et al. providing evidence of convergent genetic adaptation in hypoxic tumors and in high-altitude populations. Read this and much more here: aacrjournals.org/cancerdiscover… Vall d’Hebron Institute of Oncology (VHIO)

The May issue is online. aacrjournals.org/cancerdiscover…

Now online in Cancer Discovery: Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR-T cell Potency - by Laura Marcos-Kovandzic, Camille Bigenwald, Laurence Zitvogel, and colleagues doi.org/10.1158/2159-8… Gustave Roussy

Reach out to I-Mei (Emay) Siu if you are at #CGCecDNA!