Our latest manuscript "Lipid membranes modulate the activity of RNA through sequence-dependent interactions" is... 🎉🎊 published 🎊🎉!! pnas.org/content/119/4/… Tomasz James Saenz PNASNews VolkswagenStiftung @BMBF_Bund Simons Foundation B CUBE - Center for Molecular Bioengineering

Our work just got published in Nature Communications. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 Buchholz Lab TAKEBE Takanori Laboratory TU Dresden @Medizin_TUD rdcu.be/cFmeD

Modeling the Minimal Cell - now lipids are included, happy we could contribute! Congratulations to Zan Luthey-Schulten and Zane Thornburg University of Illinois for leading this nice collaboration with J. Craig Venter Institute and B CUBE - Center for Molecular Bioengineering TU Dresden cell.com/cell/fulltext/…

So it begins. Exciting! The RNA Society #RNA2022

Goodbye, Boulder! RNA2022 was a great experience, great job The RNA Society! #RNA22 #RNA2022

Why make many lipids? The importance of some lipids is only apparent under certain conditions. In our paper, Elise Tookmanian (she/her) shows how hopanoids can help bacteria to survive variable soil conditions, despite being dispensable in plant symbioses. tinyurl.com/4mfxwfk7 @Ra_MicroSci

What a great conference! Big thanks to organizers, presenters (both talks and posters), and all participants for making this meeting as stimulating and enjoyable as possible! @emergenceoflife

🎉 Congratulations 🎉 to Tomasz for defending his PhD thesis! Tomasz revealed how lipids can regulate RNA activity through sequence-dependent interactions. DIGS-BB TU Dresden B CUBE - Center for Molecular Bioengineering

Very excited to share the preprint of our new results in collaboration with Santen lab (Universität Saarland). We show Dynein and Kinesins can drive bidirectional vesicle transport in vitro with directional reversals, without regulators. dlvr.it/SZ9SM8

Exciting to share the 2nd paper this week - they come in bursts;) #Mathias in collab with Dorna from Deber lab uoft_biochemistry and Sáenz Lab looked at the interplay of cholesterol, a CFTR hairpin and lumacaftor #BBA authors.elsevier.com/c/1f~Op1ClSNRdq B CUBE - Center for Molecular Bioengineering also with support by Mukoviszidose e.V.

New paper alert! We have developed a method to coat microscopic beads with natural membranes, in order to study protein-protein interactions with optical tweezers: pubs.acs.org/doi/10.1021/ac… Led by Sudheer K. Cheppali! ACS Applied Materials & Interfaces

Let's talk about the 2016 University of Hawaii-Manoa lab explosion as a case study in #LabSafety practices. A few of the photos will be marked sensitive because a postdoc lost an arm in the explosion & there's blood at the scene. This story is a warning to all researchers.

Job alert. Our lab is hiring! We are looking for a PhD student or Postdoc to work on #diatom biomineralization using biochemical, molecular genetic and cell biology tools. 🔬🧬

If you fuse fluid vesicles with one that has gel domains, would you dissolve these domains? Yes. Here is how: bit.ly/3PEp2TT Biophysical Journal Thanks Rafa Cavalcanti Rafael Lira Ella Ewins & Karin Riske Max Planck Institute of Colloids and Interfaces Unifesp With the vesicles you can decorate a Christmas🎄🤩

Time to dive in the world of bacterial membranes 🦠, and #hopanoids! In our new preprint tinyurl.com/3p6xd37t we show how subtle changes to phospholipid structure can alter hopanoid (or sterol)-lipid interactions with big consequences for the membrane and the cell! #lipidtime

Adapting to cold🥶☃️: Lipidomics of Minimal Cells! Our new study explores how simple organisms like Mycoplasma mycoides & JCVI-Syn3B alter their membrane lipids with temperature change tinyurl.com/y5u3wes4 Nataliya Safronova James Saenz B CUBE - Center for Molecular Bioengineering J. Craig Venter Institute #lipidtime

We are all super proud of Anh Nguyen for winning the 🎉 Flash Talk Award 🎉 in #Graz at the Deutsche Gesellschaft für Fettwissenschaft e.V. International Symposium on Microbial Lipids...a real #Sachertorte from Vienna 🥮. Check out the preprint she presented -> tinyurl.com/yc72w4en #lipidtime B CUBE - Center for Molecular Bioengineering

Anh Nguyen 's manuscript is now published in Biophysical Journal 🥳"Varying the position of phospholipid acyl chain unsaturation modulates hopanoid and sterol ordering": cell.com/biophysj/fullt… B CUBE - Center for Molecular Bioengineering

Effects of lipid membranes on RNA catalytic activity and stability biorxiv.org/cgi/content/sh… #biorxiv_synbio

🔥RNA & lipids in action 🧬! Our latest study, featuring Tomasz as lead author, reveals how lipid membranes affect the activity of catalytic RNAs. B CUBE - Center for Molecular Bioengineering James Saenz