Directing traffic: how to effectively drive T cells into tumours. Nice mini-review from Cancer Discovery Dana-Farber Harvard Medical School Broad Institute Brigham and Women’s Research AACR Image credit: Anandappa et al. 2020 #cancer #immunotherapy #combinationtherapy

Genetically stable poliovirus vectors activate dendritic cells and prime anti-tumour CD8+ T cell #immunity in mice: go.nature.com/2GRr0xu via Nature Communications Duke University UC San Francisco #cancer #immunotherapy #oncolytic #virus #PVSRIPO #OA #openaccess Image credit: Mosaheb et al. 2020

#February11 is the International Day of Women and Girls in Science. Let's celebrate Canada’s women in science past, present and future. . #WomenInScience #WomenInSTEM #GirlsInScience #GirlsInSTEM #WomenScienceDay #InternationalDayOfWomenAndGirlsinScience #CdnSci Women in Science Day

New automated flow peptide synthesis technology produces 30-mer #neoantigen peptides in less than 35 minutes and 16-mers in less than 20 for personalised #cancer #immunotherapy: go.nature.com/2H7f9M3 via Scientific Reports Massachusetts Institute of Technology (MIT) Broad Institute Koch Institute at MIT #OA Image: Truex 2020

Genome-wide CRISPR-Cas9 screening finds a HLA-independent T cell receptor that targets #cancer vs. non-cancer cells via the MHC class I-related protein, MR1, based on sensing the cancer #metabolome: go.nature.com/2SdwRDN via Nature Immunology Cardiff University Spencer Fox Eccles School of Medicine #immunotherapy

More #evidence suggesting that the use of #antibiotics within two months of starting #immune checkpoint inhibitor #immunotherapy may have a deleterious effect in patients with advanced #cancer: bit.ly/2HbNkC8 via Springer Nature Universität Basel UniSpitalBaselCH Unispital_USZ

Say it with #Histology this #ValentinesDay❤️ . . . . All images credited to I Heart Histo . #love #science

Interesting review of the tools, methods & trends for the visual analysis of #cancer-related #genomic #data, and the serious challenges that still need to be overcome to derive clinical meaning from big datasets bit.ly/2Hsb9pA #OA #bigdata #datavisualisation Image Qu2019

Exciting new Springer Nature protocol book chapter on #oncolytic viruses, with a great focus on the immunotherapeutic effects of oncolysis, immunomodulation and immunomonitoring: bit.ly/2u9oakS H/T DKFZ #virus #cancer #immunotherapy #virology #immunology #immunity

Nice Journal for ImmunoTherapy of Cancer review of T cell-targeted #immune checkpoint inhibitor therapies in brain #cancer - where we are, and how we can achieve clinically meaningful benefits: bit.ly/2vIU6gs via National Cancer Institute #OA #openaccess #immunotherapy #immunecheckpoint #glioma

Long-term responses to PD-1 #immune checkpoint blockade are associated with stroma remodeling and reduced expression of tumour cell proliferation markers in mice & patients w/ skin #cancer go.nature.com/2P0NdxH via Nature Communications The University of Manchester #immunotherapy #OA Image Galvani 2020

Interesting model describes how spatial structures, such as solid tissues and diffusion liquids, may impact the ability of viruses to avoid innate #immunity during #infection: bit.ly/2SU2jpF via PLOS CSIC #virus #virology #OA Image credit: Segredo-Otero & Sanjuán 2020

Sequencing of serially passaged #oncolytic measles #virus demonstrates genomic stability and a robust safety profile for clinical applications: bit.ly/2SWWUzI via Microbiology Society DKFZ The Ottawa Hospital Image credit: CDC

Visualising T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones: bit.ly/2RSCoiN via Immunity University of Oxford #OA #immunology #immunity Image credit: Chauveau et al. 2020

Great Cell perspective piece describing the Human Tumour Atlas Network (HTAN), which will chart tumour transitions across space and time at the single-cell level bit.ly/3boK1Fh via Broad Institute #cancer #immunotherapy #OA #dataviz Image: Rozenblatt-Rosen 2020

Nice Cancer Cell review of intratumoural #heterogeneity, including its sources, ways to capture and account for it during clinical decision making, and potential strategies to improve therapeutic outcomes by directly targeting it: bit.ly/2XS9ItU #cancer #immunotherapy

Prime/boost treatment of #HIV patients with Ad26/Vaccinia #virus #vaccines generates robust #immune responses but only delays time to viral rebound for several days compared to placebo: go.nature.com/3eAY6RP via Nature Medicine #immunology #vaccination #publichealth

Can the site of metastasis predict treatment outcomes in #cancer patients treated with #immunotherapy ? mdpi.com/2076-393X/8/2/… Interesting #OA #research from MDPI Sapienza Università di Roma Image credit: Botticelli et al. 2020 #openaccess #metastasis

This project by Stojdl Lab is a great example of the kind of promising research being supported by Brain Canada in the field of brain cancer. To date, we have invested nearly $11M in support of work in this area #BrainTumourAwarenessMonth buff.ly/2ICezsE