How can we fill the gaps in knowledge of preterm birth - we propose bridging research areas and filing gaps with biomarker discovery frontiersin.org/journals/medic…

If complex disease is really complex, is it reasonable to take one approach to studying it?

Most genetic reports label variants as ✅ “pathogenic” or ❌ “benign.” But what patients really want to know is: what are my chances of getting the disease? 🚨 In our new Science study, we used AI + 1.3M patient records to better answer that…

What does it mean to be heritable and how variable are estimates? These are very real issues that we often downplay and just present one number. We explore this in detail for Alzheimer disease journals.plos.org/plosgenetics/a…

Many relevant corrollary questions embedded in the primary one. And of course what do different answers imply?

This needs a re-read every few years. nature.com/articles/d4158…

Always thought student evaluations were overrated in terms of assessing teaching effectiveness. They focus on short-term feedback not real learning

If you work on a laptop you can usually look at only one document or screen at a time. Whereas if you have hard copy (or multiple screens) you can put it all in front of you at same time. Does this promote linear thinking? Still use hard copies!

To what extent should we expect biological studies to reproduce? If there are unmeasured, underlying heterogeneities, same results are unexpected. Put differently how much in biology is generalizable to all samples? Must specify as much as possible about study details

In all seriousness, the damage @nature and its homologs have done to science by equating flashy results to progress is incalculable.

Do no harm - out the window... scrippsnews.com/health/fda-com…

Our latest in Nature Communications where we used stratified male/female analyses to infer genetic architecture. In favor of omnigenic model? rdcu.be/eITWv

The real damage is not immediate, and that is a big part of the problem in a transactional world

Every time I take a new online "course" how to be a decent human being and not a threat to national security I am reassured that the world is a better place. What did we do before these were available?

If everything you do works, you are limiting what you can learn

As a student learning to do science well is the number one task. Papers (good ones) will follow if you do that.

Academic research historically focused on basic discovery. This provided knowledge to leverage into economic growth and improving human condition. This is being transformed into the academy explicitly providing translatable product. Forcing translation is far too short sighted

WOW! Money well spent?