Epigenetic priming as a driver of memory recall and dysfunction in T cells. A new review from Mieke Metzemaekers, Niels Rinzema, and Ralph Stadhouders: hubs.la/Q03zNqkl0 #LymphocyteBiology #MucosalImmunology #TumorImmunology #Epigenetics #Cancer

Huge congratulations to Xiling Shen MD Anderson Cancer Center and Ayelet Erez Weizmann Institute for their Cell paper: Vagal blockade of the brain-liver axis deters cancer-associated cachexia cell.com/cell/abstract/… Clinical trials in patients with #PancreaticCancer forthcoming!

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA dlvr.it/TMNCmm

3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons - and the ability to put together amazing teams of collaborators. Somehow, CureSearch had faith in us! 🧵 cell.com/cell-reports/f…

BATF is a pioneer initiating chromatin reorganization upon antigen encounters and heterodimerizes with IRF4 to drive the dynamic rearrangement of epigenomic and transcriptomic landscapes in effector differentiation of CD8+ T cells Cell Reports cell.com/cell-reports/f…

Online now: Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells dlvr.it/TMNMdz

#Breaking: Vinay Prasad is returning to the Food and Drug Administration to resume his role overseeing vaccine, gene therapy, and blood product regulation. trib.al/wcFLRDr

Cancer-related cachexia is responsible for ~1/3 of cancer deaths, yet its causes & treatments have proven elusive—until now. In Cell, Endeavor Award team leader Ayelet Erez identifies a cause for the syndrome—and a path forward for patients. cell.com/cell/abstract/…

Preclinical Efficacy of Multi-targeting mRNA-based CAR T Cell Therapy in Resection Models of Glioblastoma dlvr.it/TMRL7C #MTNA

Transcriptomic analysis reveals lung cancer and subtype-specific alternative splicing biomarkers regulated by RNA-binding proteins dlvr.it/TMSP3d #MTNA

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard

How to standout as a leader. (and tips to put each one into action 🧵)

New #JITC review: Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction bit.ly/3UmKgsD

Platelets sequester and harbor cell-free tumor DNA, which could enhance our ability to make early, microscopic diagnosis of cancer Science Magazine science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

News from the T cell trogocytosis front dlvr.it/TMVJCv #immunology

A discovery doesn't usually happen as a single moment but in 3 phases: 1. Observing the results from experiments & analyses, 2. Realizing the big story when writing up the paper, 3. Understanding what's truly new about the work when presenting to friends, reviewers & audiences.

New online! Tracing the evolution of sequencing into the era of genomic medicine bit.ly/45lEYUB

OK. What does this actually mean in practice?! That POs can just pick and choose which grants to fund?

The classic hourglass structure of paper writing

If you are looking for a great read during your journey to International Union of Immunological Societies Congress, take a peek at this review from Matthias Nahrendorf, @Fginhoux and Fil Swirski & Scientists in Science Magazine that explores the role of immune cells beyond host defence. buff.ly/S5RkqTf