What is the cause of RARE cases of myocarditis following COVID-19 mRNA vaccination? Read our hypothesis & our plan to answer the Q: rdcu.be/cW7IX Thankful to work with a great team of scientists & physicians from all over the world. Details in 🧵

Prof. Casanova illustrating how 2 papers on 4 children with inborn errors of immunity can result in the discovery of the underlying cause of 2 million COVID19 deaths. #ESID2022 Casanova Lab

#ESID2022 reunion (on ABBA tunes) for half the original “NY mycobacteria group” Casanova Lab with Dr Vanessa Bryant, Satoshi Okada and BogunovicLab 🤩 -and amazing science by each of them! (missing Carolina Prando, Xiao-Fei Kong, Marcela Moncada-Velez and of course Stephanie_Boisson-Dupuis)

A new paper by Hirokazu Kanegane et al: “Novel STAT1 Variants in Japanese Patients with Isolated Mendelian Susceptibility to Mycobacterial Diseases” in Journal of Clinical Immunology. HP: tmd.ac.jp/english/press-… DOI: doi.org/10.1007/s10875… #東京医科歯科大学 #tmdu

【研究成果発表】 「メンデル遺伝型マイコバクテリア易感染症（MSMD）を見逃さない」－MSMDの原因としてSTAT1異常症が多い－（大学院医歯学総合研究科 寄附講座教授 金兼 弘和） プレスリリース tmd.ac.jp/press-release/… DOI: doi.org/10.1007/s10875… ＃東京医科歯科大学 #tmdu

Dominant-negative mutations in RELA thus underlie a novel form of type I interferonopathy with systemic autoinflammatory and autoimmune manifestations due to excessive IFN, probably triggered by otherwise non-pathogenic TLR ligands Journal of Experimental Medicine doi.org/10.1084/jem.20…

Moriya, Nakano, Satoshi Okada @Hiroshima_Uni et al. establish a novel form of IEI due to DN RELA mutations as a cause of chronic mucocutaneous ulcerations with autoinflammatory and/or autoimmune manifestations. bit.ly/3OUwzzq Casanova Lab #Immunodeficiency

Beautiful paper expanding the fields of inborn errors of NF-kB and type I interferonopathies !

Casanova Lab Great job! Don't forget this one :-)

1/ Presentations, peaks and #puffins! After reaching 7 summits ⛰️and taking the ferry ⛴️ to #Mykines where we saw the amazing puffins, we reconvened to hear fascinating talks on #CMC, #mycobacteria, #HPV, #liverdisease, #autoAbs, #genetherapy, and many other exciting topics! 🦠

Back home after a week of amazing science, hikes and (old & new) friendships at the 2nd International Symposium on Inborn Errors of Immunity (#IEI) in the Northern Atlantic with current and previous HGID lab members 🇫🇴 Thank you Casanova Lab

link.springer.com/article/10.100…

Bastard, Aurelie Cobat, Casanova Lab and colleagues find that auto-Abs against IFN-α confer a greater risk of #COVID19 pneumonia in children. hubs.la/Q02fkJ8v0

Patients with STAT1 GOF have an Ab deficiency: link.springer.com/article/10.100…

I am thrilled to become the Editor of this new journal and grateful to both RUP and IAPIDS for their trust ! I also thank Megan Cooper who graciously accepted to become the Deputy Editor !

1/ We are proud of our former trainees and will be highlighting their accomplishments from time-to-time. First up is Satoshi Okada, appointed Chief Professor of the Department of Pediatrics at Hiroshima University in 2020 and advanced to Head of the Program of Medicine in 2024.

6/ Inspired by hikes with our lab, Satoshi Okada resumed hiking last year. Here he is with his medical dept atop Mt Daisen, one of Japan's 100 famous mountains, 3-4 hours from Hiroshima. All 18 members of his team, with their kids, made it to the summit, a climb of 1,000 meters!

7/ Satoshi Okada also climbed Mt. Fuji last year! Keep climbing, Satoshi!