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sciencedirect.com/science/articl… GPAT1 deficiency protects mice against NASH in a dietary model-dependent manner. #MASLD #MASH #LiverTwitter CMGH

Excited to share that I will be presenting a poster at the AASLD TLM 2023 tomorrow from 1pm-2pm. My poster number is 1707-A & I will be there at Hall-A (Plaza Level) of Hynes Convention Center, Boston. Anyone attending the meeting, please do drop by! #aasld

What an absolutely enriching experience it was presenting a part of my research work at AASLD TLM 2023. It felt wonderful to have received such valuable insights and useful suggestions for my study. It was indeed a great experience. #TLM2023 #AASLD

Extremely grateful to AASLD for setting the perfect platform for us to be among the stalwarts from liver research and hear them share their groundbreaking studies over a period of 5 days. It’s been nothing short of an enlightening experience! #TLM2023 #AASLD

Sharing my first co-first author paper which reports the discovery & development of first-in-class small molecules which inhibit COP1's ability to ubiquitinate ATGL & abrogate hepatic steatosis by increasing lipolysis. #livertwitter pubs.acs.org/doi/10.1021/ac…

Congratulations to Arindam Talukdar and Partha Chakrabarti labs! J Med Chem ACS Publications: a small molecule curbs ATGL ubiquitination by the E3 ubi ligase COP1, enhances hepatic lipolysis and reverses hepatic steatosis. CSIR, India Vibha Tandon DSTIndia Department of Biotechnology pubs.acs.org/doi/10.1021/ac…

dm5migu4zj3pb.cloudfront.net/manuscripts/16… TRIM56, which ubiquitiantes FASN, could be a potential target for ameliorating NAFLD. An AI-based virtual screening identified FASstatin, which helped to combat the disease in mice. Fascinating feat on the AI front! #livertwitter

onlinelibrary.wiley.com/doi/10.1002/jc… The study shows IL-38 as a potent therapeutic target for combating steatosis by reversing ER stress through AMPK/autophagy dependent signalling and elevation of fatty acid oxidation. #livertwitter

sciencedirect.com/science/articl… MOTS-c improves acyl-carnitine shuttle & TCA cycle in NASH livers. It prevents ubiquitination of Bcl-2 by binding to it & thus increasing its stability. MOTS-c improves mitochondrial homeostasis & alleviates NASH. #livertwitter #masld

nature.com/articles/s4139… Zbtb18 promotes transcriptional activation of FXR-mediated FAO & CLTC expression which hinders activity of NLRP3 inflammasome, thereby mitigating inflammatory stress & insulin resistance. Zbtb18 could be a promising target in hepatic steatosis & fibrosis.

nature.com/articles/s4146… The study reports that stimulating glycolysis through the activation of Kupffer cell G-protein coupled receptor 3 (GPR3) safeguards mice against obesity and fatty liver disease. #livertwitter Nature Communications

sciencedirect.com/science/articl… Amphiregulin producing Treg cells play a detrimental role in tissue repair functions, connecting liver damage to glucose intolerance dependent on NASH. Amphiregulin triggers fibrosis in hepatic stellate cells through EGFR signalling.

sciencedirect.com/science/articl… 1-PPA administration successfully blocked the PAR2-C/EBP-β-SerpinB3 axis, providing protection against NASH development & progression supporting the potential application of a comparable approach for targeted therapy in treating NASH.

sciencedirect.com/science/articl… Induction of TAp63 expression occurs in mice HSCs & patients with liver fibrosis. TAp63 can trigger HSC activation and stimulate fibrosis by modulating the HER2-ACC1 axis. #livertwitter #MASLD

nature.com/articles/s4146… SHH deubiquitylates HSP90β via USP31 mediating hepatic lipid synthesis. HSP90β causes secretion of miR-28-5p which degrades Rap1b promoting NF-κB transcriptional activity in macrophages triggering inflammation. #LiverTwitter

sciencedirect.com/science/articl…

sciencedirect.com/science/articl… Implications of GPR75 in hepatic lipid accumulation and NAFLD management.

pdf.sciencedirectassets.com/272415/1-s2.0-… O-GlcNacylation and CD36 elevation in NASH.

nature.com/articles/s4158… Fascinating study whereby postbiotic from commensal bacteria influences self-limiting hepatic inflammatory response around periportal region driven by distinct set of macrophages leading to reduced hepatic inflammation. #LiverTwitter

sciencedirect.com/science/articl… EFHD2 in amelioration of NASH