Very happy to see our latest paper published in @TheLancetPsych! We used population pharmacokinetic and pharmacogenomic approaches to better understand lithium clearance. authors.elsevier.com/a/1f3d57tf1d1D……

An analysis of GWAS reveals sex-specific genetic correlations between body fat %, fat mass, fat-free mass, physical activity, and 17 psychiatric traits, including anorexia nervosa and schizophrenia. rdcu.be/cN5zQ Topher Hübel @cbulik@psychgenomics #EatingDisorders

World Eating Disorders Action Day is June 2, 2022. This year we care about those who care for people affected by eating disorders. worldeatingdisordersday.org via WorldEDday #EatingDisorders

I got rhythm... A molecular genetic study of beat synchronization in >600k individuals, by Maria Niarchou (she/her), Reyna Gordon & colleagues, is the first largescale systematic investigation of genomics of a musicality trait, & it's published today in Nature Human Behaviour: nature.com/articles/s4156…

Here's the latest from our lab Prof. Thomas G. Schulze 🎗INDEPENDENT Libertarian Sergi Papiol @kalman_jl @moni_budde Manuel Mattheisen Eva Schulte Lithium response in bipolar disorder: Genetics, genomics, and beyond sciencedirect.com/science/articl…

"Insomnia is currently estimated to be the third most polygenic trait, following major depressive disorder (MDD) and educational attainment" nature.com/articles/s4158…

German study suggests CYP2C19 metabolizer status may inform venlafaxine dosing. CYP2D6 also important, of course. pubmed.ncbi.nlm.nih.gov/35839823/ Andreas Menke Universitätsklinikum Würzburg Pharmacopsychiatry

very useful 5 Simple Design Principles for a Grant Proposal Figure Makeover by Pattern link.medium.com/vHUJsmrASrb

the latest insomnia GWAS notes that “insomnia is currently estimated to be the third most polygenic trait, following major depressive disorder and educational attainment.” we know the level of non-direct effects in population GWAS estimates are related to a trait’s polygenicity.

Very happy to share this pre-print from the PGC Suicide Working Group and the Million Veteran Program, “Genome-wide association study meta-analysis of suicide attempt in 43,871 cases identifies twelve genome-wide significant loci” Huntsman Mental Health Institute PGC Consortium medrxiv.org/content/10.110…

I’m happy to share a preprint of our new GWAS of depression, identifying 64 new risk loci, refining the genetic architecture and predicting risk of recurrence and comorbidities. medrxiv.org/content/10.110…

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities medrxiv.org/content/10.110…

Fetal pharmacogenomics. Study demonstrates the potential of PGx as useful preemptive clinical information that could be obtained at the time of fetal exome sequencing for other indications. pubmed.ncbi.nlm.nih.gov/36029725/

Effects of #CYP2C19 and #CYP2D6 gene variants on #escitalopram and #aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study nature.com/articles/s4139…

Perfect reunion at #WCPG2022 🇮🇹 - the first one in person since 2019! 🥳😷 With Cal Liao Vincent Millischer Kathrin Kreuzer DrS Qin HE Topher Hübel Anna and more!

Daniel J. Mueller 🧠🔬 is presenting the recommendations for pharmacogenetics in psychiatry at #WCPG2022

The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis #GutMicrobiome #Circadian nature.com/articles/s4146…

Manhattan plots highlighting GWAS genes that are targets of approved drugs. Nice! From a preprint "Using genome-wide association results to identify drug repurposing candidates" by Nathaniel, Emil (@euffelmann.bsky.social) Danielle and colleagues. medrxiv.org/content/10.110…

In April, the Bipolar Exome collab analysed whole-exome sequencing data of 13,933 patients with #BD The study highlighted AKAP11 as a shared risk gene with schizophrenia and implicates ultra-rare damaging variation in BD sub-types! 🧬 Led by Duncan Palmer bit.ly/3ekVMmV

New very interesting review in Nature Reviews Genetics on the Genetics of circadian rhythms and sleep in human health and disease nature.com/articles/s4157…