A powerful new tool can predict the mutations that allow viruses, like #SARSCoV2, to “escape” human immunity or vaccines, a new Science study finds. The research represents a promising conceptual bridge between natural language and viral evolution. ($) fcld.ly/4g8xctq

We are once again asking if anyone knows this man who's been hanging around our downtown campus all week. #BernieMemes #BerniesMittens Bernie Sanders

Virus vaccines: proteins prefer prolines. Sanders & Moore review a method devised for #HIV #vaccine development that was utilized in most #COVID19 vaccines-- stabilization of the spike protein by appropriately positioned proline amino acid substitutions cell.com/cell-host-micr…

One of the most startling Covid charts I’ve made in a long time, on vaccine inequality: Rich countries have given out more booster shots in the last 3 months, than poor countries have given out total doses all year. donato’s story: ft.com/content/35a3d4…

"In Pakistan, more than 40 million children were unable to receive measles vaccination and around 50 million children missed polio vaccination in 2020. Moreover, more than 36 million children did not receive vitamin A supplementation in 2020."

This 🧵is a layman's understanding regarding virus pathogenicity and evolution: science only says that viruses which kill all their hosts will disappear. That's all. From this, it doesn't follow that viruses have an "inner desire" not to kill their hosts or to become milder.

Phenomenal paper just published in Science persuasively demonstrating that EBV causes most if not all multiple sclerosis. Phenomenal epidemiological design and technical achievement. 👏 science.org/doi/10.1126/sc…

Our SARS-CoV-2 nanovaccine paper is out! We describe the development of immune-focused receptor-binding domain nanoparticle vaccines which elicit potent and durable neutralizing antibodies against SARS-CoV-2 and variants of concern. Cell Reports sciencedirect.com/science/articl…

Our latest HIV vaccine paper is out! We demonstrate that an Env-encoded nucleic acid vaccine retains a native-like trimer antigenic profile in vivo and results in unique neutralization which we mapped by cryo-EM. nature.com/articles/s4146…

Incredible paper out in nature nature.com/articles/s4158…

Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities biorxiv.org/cgi/content/sh… #bioRxiv

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies dlvr.it/SWWDgX

Why are Pakistan’s floods so extreme this year? nature.com/articles/d4158…

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies biorxiv.org/cgi/content/sh… #biorxiv_immuno

Great and productive #CAVDannualMeeting by Gates Foundation in Seattle last week. We presented our work generating #NewMouseModels for #HIV #Vaccine development by Belen Palacio Bel, Ignacio R. Relaño Ignacio R. Relaño and Ashwin Skelly at The Wistar Institute

We developed a new multivalent mRNA vaccine against all known influenza virus subtypes. Our study describing the vaccine was just published in Science Magazine. 1/n science.org/doi/10.1126/sc…

Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! nature nature.com/articles/s4158…

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene biorxiv.org/cgi/content/sh… #bioRxiv

Enjoying a great #HIVR4P2024 meeting by IAS - the International AIDS Society with Ignacio R. Relaño and Rumi Habib from The Wistar Institute in Lima this week😍. Thank you to the Gates Foundation for hosting a fun reception this evening. #HIVvaccines 💪