Wonderful collaboration with Aleksandra Filipovska reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. Science Magazine science.org/doi/10.1126/sc…

Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens - PubMed pubmed.ncbi.nlm.nih.gov/37140391/

Confused about biomolecular condensates? Check out our latest review: genesdev.cshlp.org/content/early/… Many thanks to G&D and the anonymous reviewers for an awesome review process!

It's time for #MicrobeoftheMonth! Who am I? 1) I’m a zoonotic pathogen. 2) I am nonmotile. 3) I have caused 3 DNA-verified pandemics during recorded history. Think you know? Leave a guess below!

Dropping the anchor, how to TRAP a ribosome at the ER membrane! Check out our new study describing a structure of TRAP complex interacting with the ribosome and Sec translocon published today in NatureStructMolBiol nature.com/articles/s4159…

This is a really cool tool! A generator almost as amazing as nature itself.

Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway | Matus Valach et al. academic.oup.com/nar/advance-ar…

Still not where we've been Physics at Freie Universität Berlin but on a good way to get our Krios running after the relocation to #suprafab Freie Universität Thanks for your patience to our users, keep fingers 🤞

Check out our new study in @sciencemagazine. We show that NAC controls N-terminal methionine excision by MetAP1 in eukaryotes. Our results suggest a broader mechanism for how access of protein biogenesis factors to the translating ribosome is controlled. bit.ly/42SU6nN

check out our Spotlight Article Trends in Genetics 🔥 hot 🔥 off the press! teamed up with Olivier Duss (EMBL Heidelberg) & Rainer Nikolay (MPI for Molecular Genetics) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from Scott C Blanchard open access 👇 authors.elsevier.com/a/1hJjvcQbJ7Wti

Here is the original article on the “molecular de-extinction” of the antimicrobial peptides doi.org/10.1016/j.chom…

Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!

"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ cell.com/cell/fulltext/… Our new review is online Cell. Big thanks to our amazing co-authors @computingCaitie Sven Klumpe Rommie Amaro Wanda Kukulski @EM_STP

I am very glad to share our paper on 30S turnover!Thank you Helge and Daniel (WilsonLab ) for letting me be part of that fantastic story! I would also use the occasion to thank the collaborators and reviewers for helping us shape this work! nature.com/articles/s4158…

Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma JBacteriology Eds Mini Review by Andrei Kuzminov journals.asm.org/doi/10.1128/jb…

Bacterial growth rate modulation is typically associated with genetic or environmental changes. In this preprint, we show that growth rate in Caulobacter varies between daughter cells in the same environment. Led by (brand-new) Dr. Skye Glenn. #ppGpp biorxiv.org/content/10.110…

Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in Nature Communications Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. rdcu.be/dHxGL nature.com/articles/s4146…

Scientists from Beck Laboratory, Max Planck Institute of Biophysics, @EMBL, including Iskander Khusainov use #cryoET #teamtomo to compare the response of human gut and laboratory E. coli strains to the antibiotic tetracycline nature.com/articles/s4146…

Excited to share our recent work “A Roadmap for Ribosome Assembly in Human Mitochondria” NatureStructMolBiol A great team effort together with the groups of Henning Urlaub and Juliane Liepe. Fantastic work by Elena Lavdovskaia. Thanks to everyone involved. nature.com/articles/s4159…

Excited to share our new work on the proline-rich antimicrobial peptide Api137, which disrupts large ribosomal subunit assembly and induces RNA misfolding. Big thanks to the Spahn & Hoffmann groups for this amazing collaboration! rdcu.be/d5RsS