#AF3 is amazing but the webserver does not display all scores needed to evaluate a model. Our Colab-based AlphaFold3 score visualizer helps! Check it out at colab.research.google.com/drive/1YB2378j… Thanks to Robin Schaeper!

Researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/6Zk

Coordinated wound responses in a regenerative animal-algal holobiont | Nature Communications nature.com/articles/s4146…

A cancer cell with two nuclei photographed through a microscope. DNA (yellow), mitochondria (blue/purple), and actin filaments (red) are shown. #CellBiology

🤩🤩🤩 Kinetics of interorganelle lipid flux in cells!! So many things I’ve wanted to know and never seen measured. Fantastic!

The energy invested in animal reproduction is as much as 10 times greater than previously estimated, according to a new Science study. The findings fundamentally challenge longstanding theories and biological models of animal growth and life histories. scim.ag/74l

Another amazing flotillin structure. Is this the same complex as @ChlandaL observed in 2021 on lamellar bodies but could not identify? Dimensions match! nature.com/articles/s4200…

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Introducing aerotrophy! New preprint shows that aerated caves are continually energised by atmospheric trace gases. The most abundant and active microbes fix carbon using hydrogen and methane gas. Huge collective effort led with @Sean_K_Bay and @chownlab. biorxiv.org/content/10.110…

We are excited to be opening 2 Ph.D. and 1 post-doc positions to work on cryo-EM and computational biology of plant protein complexes & their proteoforms (Projects A04, C04 and D01)! Visit snp2prot.uni-halle.de to be informed and apply ASAP! #SFB1664, headed by quintlab

In our new paper at Cell (Cell), we reveal secrets of how the third form of life, archaea, make energy. We uncover new lineages of hydrogen-using enzymes, both minimal and complex. These help archaea thrive in all sorts of extreme environments. sciencedirect.com/science/articl…

Our paper on the structure of twitching pili from the archaeon S. acidocaldarius is finally out in Nat Comms! nature.com/articles/s4146…. Thanks the authors Matt Gaines, Shamphavi Sivabalasarma, Misha Isupov, Risat Haque, @cyril_hanus, mathewmclaren, Vicki Gold, @archaellum.

Here we review the state of cryo-FIB, challenges in structural biology, and provide future prospectives: authors.elsevier.com/sd/article/S09…

To #TeamTomo ❄️🔬: Do you also sometimes see strange filaments in your #cryoET data and don’t know what they are? 🤔 Try #FilamentID! 🪄🤓 Check out our new paper at Cell by @HugenerJannik and Jingwei Xu together with the Matos lab cell.com/cell/fulltext/… 🧵(1/5)

Exciting news!🚀 We have a new follow-up on the cytoplasmic Contractile Injection System from #Streptomyces!💉casu_b, in a wonderful collaboration with Joe Sallmen & Susan Schlimpert, unveils the critical role of CisA in Streptomyces CIS functionality. ☠️🧵 1/2

The peer-reviewed version of our manuscript on the design of a #COVID19 vaccine candidate largely insensitive to viral evolution based on prefusion-stabilization of the spike fusion machinery is out! Led by 이지민 HHMI UW Biochemistry 1/4 nature.com/articles/s4146…

Check out our latest work! 👇We leverage pretrained protein generative models (here Chroma Generate:Biomedicines ) as a prior for inverse problems in protein space (e.g. structure completion, distance contraints, cryo-EM model building). ❄️🏗️ Paper: arxiv.org/abs/2406.04239

Our latest: Using de novo protein structure prediction and sensitive sequence searches we found many new eukaryotic signature proteins in Asgard archaea, suggesting the archaeal ancestor of eukaryotes was more complex than previously assumed. Stephan Köstlbacher biorxiv.org/content/10.110…

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/sh…

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