PREdiCCt (@predicct) 's Twitter Profile
PREdiCCt

@predicct

A #bigdata study looking to increase understanding of how #environment, lifestyle, #diet, genetics & the #microbiome influence flare in #Crohn's disease & #UC.

ID: 4170634401

linkhttp://www.predicct.co.uk calendar_today12-11-2015 10:51:15

1,1K Tweet

2,2K Followers

208 Following

Charlie Lees (@charlie_lees) 's Twitter Profile Photo

I've started to think about life for our patients post-pandemic. We face many challenges but I'm optimistic. Advances in drug development, genomics, digital health, AI & more. This is the start of a new series on Innovations in IBD & the story of the innovators. #ship30for30

I've started to think about life for our patients post-pandemic. 

We face many challenges but I'm optimistic.

Advances in drug development, genomics, digital health, AI & more.

This is the start of a new series on Innovations in IBD & the story of the innovators. 
#ship30for30
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

We asked 1946 patients with Crohn's and UC in remission about fatigue: here's what we found. 40% of patients were fatigued >50% of the time. Factors associated with fatigue • depression & anxiety • clinical disease activity • female sex and higher BMI @PREdiCCt #Ship30for30

We asked 1946 patients with Crohn's and UC in remission about fatigue: here's what we found.

40% of patients were fatigued >50% of the time.

Factors associated with fatigue
• depression & anxiety
• clinical disease activity
• female sex and higher BMI

@PREdiCCt #Ship30for30
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

What causes disease flares in IBD? We asked the 2639 participants of the @PREdiCCt study in their baseline questionnaire. 1946 replied - these were their top responses • stress (69.8%) • dietary changes (46.8%) • alcohol (19%) • sleep disturbance (17%) #ship30for30

What causes disease flares in IBD?

We asked the 2639 participants of the @PREdiCCt study in their baseline questionnaire. 

1946 replied - these were their top responses
• stress (69.8%) 
• dietary changes (46.8%)
• alcohol (19%)
• sleep disturbance (17%)

#ship30for30
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

I have a big favour to ask. Have you taken part in the PREdiCCt study? Then we need your help. Please log into the PREdiCCt portal and complete the final questionniare. Here is why this is so important and a big thank you. Crohn's & Colitis UK Cure Crohn's Colitis - Funding IBD research

I have a big favour to ask. 

Have you taken part in the <a href="/PREdiCCt/">PREdiCCt</a> study? Then we need your help.

Please log into the PREdiCCt portal and complete the final questionniare. 

Here is why this is so important and a big thank you.

<a href="/crohnscolitisUK/">Crohn's & Colitis UK</a> <a href="/crohnscolitisc3/">Cure Crohn's Colitis - Funding IBD research</a>
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

Multiple environmental factors impact the gut in health and inflammatory bowel disease: • diet • sleep • travel • stress • surgery • hygiene • exercise • smoking • geography • emulsifiers • medications Important to take a HOLISTIC approach to health and disease.

Multiple environmental factors impact the gut in health and inflammatory bowel disease:

• diet
• sleep
• travel
• stress
• surgery
• hygiene
• exercise
• smoking
• geography
• emulsifiers
• medications

Important to take a HOLISTIC approach to health and disease.
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

What happens when the delicate balance between environment, genes and microbiota is disrupted? Inflammatory bowel disease (IBD) can develop Crohn's disease and ulcerative colitis now affect 1 in 125 people in the developed world. The numbers are going up fast elsewhere.

Charlie Lees (@charlie_lees) 's Twitter Profile Photo

Prevention and cure are big words with a big impact. But are they possible in IBD? I've mapped out some of the key steps to move us to preventing IBD. Data are coming ... #ship30for30

Prevention and cure are big words with a big impact.

But are they possible in IBD?

I've mapped out some of the key steps to move us to preventing IBD.

Data are coming ...

#ship30for30
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

Day 13 of #ship30for30 paging all PREdiCCt participants and requesting you complete the final follow-up questionnaire please x.com/charlie_lees/s…

Kevin Whelan (@profwhelan) 's Twitter Profile Photo

Meta-analysis of studies of nutrient intake in #InflammatoryBowelDisease #IBD #Crohns #Colitis Low intake of fibre is strongest and most consistent finding How can we help people with IBD to increase #fibre intake? Full paper Georgina Hold roypounder.apt 👉🏽 onlinelibrary.wiley.com/doi/10.1111/ap…

Meta-analysis of studies of nutrient intake in #InflammatoryBowelDisease #IBD #Crohns #Colitis

Low intake of fibre is strongest and most consistent finding

How can we help people with IBD to increase #fibre intake?

Full paper <a href="/HoldGeorgina/">Georgina Hold</a> <a href="/APandT/">roypounder.apt</a> 👉🏽 onlinelibrary.wiley.com/doi/10.1111/ap…
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

We are developing and testing increasingly targeted therapies for Crohn's disease & ulcerative colitis. New molecules will hopefully bring increased efficacy with minimal / no safety issues. Not all will make it to market - some have already failed. But there is more to come.

We are developing and testing increasingly targeted therapies for Crohn's disease &amp; ulcerative colitis.

New molecules will hopefully bring increased efficacy with minimal / no safety issues.

Not all will make it to market - some have already failed.

But there is more to come.
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

The environmental pressures on a modern gut are undoubtedly different from those of our hunter-gatherer ancestors. The microbiomes would reflect this. What does this mean for us today? The paleo vs plant-based debate shows this is complex. More data would help!

The environmental pressures on a modern gut are undoubtedly different from those of our hunter-gatherer ancestors. The microbiomes would reflect this.

What does this mean for us today? 

The paleo vs plant-based debate shows this is complex. 

More data would help!
PREdiCCt (@predicct) 's Twitter Profile Photo

A reminder about our important study TO ALL PARTICIPANTS: - please log into the portal and complete a questionnaire today - it doesn't matter how late it is - late is definitely better than never Thank you

A reminder about our important study

TO ALL PARTICIPANTS:
 - please log into the portal and complete a questionnaire today 
 - it doesn't matter how late it is
 - late is definitely better than never

Thank you
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

The impact of Crohn's disease and UC on a person's life can be devastating. With 1 in 125 of the population living with #IBD it is important we realise what they might be going through. It isn't just physical; here 👇 are just some of the ways IBD affects people.

The impact of Crohn's disease and UC on a person's life can be devastating.

With 1 in 125 of the population living with #IBD it is important we realise what they might be going through.

It isn't just physical; here 👇 are just some of the ways IBD affects people.
Charlie Lees (@charlie_lees) 's Twitter Profile Photo

We now have clear guidance from JCVI on those patients eligible for a 3rd primary dose of COVID vaccine. This includes IBD patients on infliximab, adalimumab, ustekinumab, tofacitinib, prednisolone and some on high-dose aza/mp/mtx. Details here & below gov.uk/government/pub…

We now have clear guidance from JCVI on those patients eligible for a 3rd primary dose of COVID vaccine.

This includes IBD patients on infliximab, adalimumab, ustekinumab, tofacitinib, prednisolone and some on high-dose aza/mp/mtx.

Details here &amp; below

gov.uk/government/pub…
CLARITY IBD (@clarityibd) 's Twitter Profile Photo

Hey folks 👋 Do you want to know more about CLARITY IBD? ✅how/why it started? The latest results and what they mean? Then do watch the talk by Dr Tariq Ahmad (CLARITY IBD very own 🎩🌟) Annual General Meeting 2021 | Crohn's & Colitis UK shar.es/aWCAtR