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KB: So today we are pleased to introduce the Chromium Single Cell ATAC + Gene Expression solution. 2 modalities in one simple workflow, both at high sensitivity. #AGBT20

With Fei Chen's lab, we increase Slide-seq mRNA detection 10-fold, transforming what we can discover in these data. It's our last preprint as we prepare to shut down the lab for #COVID19. Time to catch up on #bioRxiv reading! Stay healthy. biorxiv.org/content/10.110…

The landscape of human cells! From Guoji Guo's lab- single-cell RNA-seq of 500,000 cells across 60 human tissues. Also includes biological replicates, detailed annotation, and open code/data: nature.com/articles/s4158…

Cell atlas projects and single-cell perturbation screens require cost-effective profiling for millions of cells or thousands of experimental conditions. Our new method scifi-RNA-seq supports projects of this scale. Article published today Nature Methods: nature.com/articles/s4159…

Compared to our preprint the article includes extensive benchmarking to 10x Genomics and plate-based combinatorial indexing. We included a CRISPR screen with scRNA-seq readout of T cell activation. Round1 barcodes are ideal for large perturbation screens with single-cell readout.

I prepared this Tweetorial as a quick introduction to the scifi-RNA-seq technology. Please check it out if you are interested in ultra-high-throughput and highly multiplexed scRNA-seq.

scifi-RNA-seq improves the throughput of droplet-based scRNA-seq up to sequencing millions of cells in a single experiment. Christoph Bock Lab @ CeMM & MedUni Vienna CeMM nature.com/articles/s4159…

Integrated scATAC/scRNA-seq analysis of TILs, elegantly validated by enhancer editing. Congratulations to Christian Schmidl and team on this beautiful story and the first paper from the new lab!

Press release: businesswire.com/news/home/2024…

"If you asked an AI to generate a brand-new drug discovery biotech with a team of some of the biggest names in the biz for you, it couldn’t dream up one like Xaira Therapeutics." fiercebiotech.com/biotech/new-ai…

🧬Evo, the first foundation model trained at scale on DNA, is a Rosetta Stone for biology. DNA, RNA, and proteins are the fundamental molecules of life—and cracking the code of their complex language is an ongoing grand challenge. 🔬Today in Science Magazine, the labs of Arc

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

Enjoyed writing this perspective on an AI-powered virtual cell with amazing collaborators But it’s been even more fun actually building it! 🔧 Check out open positions @ArcInstitute or find us NeurIPS Conference

Interested to screen T cells for Arc’s Virtual Cell Initiative and explore AI virtual cells in cancer immunotherapy? I’m looking for a talented Scientist to join my team at the Arc Institute in Palo Alto, California. Apply here! grnh.se/c565d05f4us

Today, Arc announced it is joining forces with NVIDIA Healthcare to develop powerful computational tools that will help researchers everywhere explore and understand living systems in ways previously impossible. arcinstitute.org/news/news/arc-…

Excited to partner with @Nvidia and NVIDIA Healthcare to scale the potential of AI models to design, predict, and understand biology. Our goal is to discover emergent properties of life, similar to those found in language, videos, and robotics arcinstitute.org/news/news/arc-…