Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬 A team effort with Andrew Payne, Paul Reginato, Ed Boyden, Jason Buenrostro, and Fei Chen science.sciencemag.org/content/early/… This is how it works: (1/8)

We're searching for a new postdoctoral researcher to join the lab. Please help spread the word.

We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.

Excited to share that our 9-year research effort has been published in nature. We found that the mechanisms from long-lived species can be replicated and proven functional in other species. Congrats to Gorbunova, Gladyshev Lab and Prof Steve Horvath labs. doi.org/10.1038/s41586…

🎉 1/8 We are thrilled to unveil our inaugural publication, now available in Cell. This achievement marks a significant milestone resulting from our collaborative endeavors with prominent leaders in aging, contributing to the Biomarkers of Aging Consortium.

Pleased to share an opinion piece I wrote with Vadim Gladyshev just published in @PNASnews. We discuss what I consider to be the most pressing (and interesting!) question in the field: what is aging? doi.org/10.1073/pnas.2…

Huge congrats to Nan Yao, his advisor Bob Schmitz, and their collaborators on their new paper: An evolutionary epigenetic clock in plants science.org/doi/10.1126/sc…

Congratulations HSCRB Associate Professor Jason Buenrostro for being been named a 2023 #MacFellow! MacArthur Foundation macfound.org/fellows/class-…

Xiao is one of the most productive and kindest scientists I have ever met! Amazing opportunity

Can we shield the epigenome from age-related changes, much like how SIRT6 defends the genome? Using a CRISPRi screening approach, Xiao Tian seeks to identify genes involved in maintaining epigenome stability. His new lab Sanford Burnham Prebys is recruiting for various roles!

Delving into our newly released result, a thread:

Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.110… we used 🧬 screens to find new rejuvenation factors🧵1/8

Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin! Nature Aging Free download rdcu.be/dvDfc

We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!

Study Proposes Framework to Standardize Biomarkers of Aging and Accelerate Clinical Use Jesse Poganik Read more: buff.ly/3OMHMBo

T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this

Grades of DNA methylation as the basis of epigenetic cell memory... must-read. biorxiv.org/content/10.110…

Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬Ajay Labade zack chiang Caroline Comenho nature.com/articles/d4158…

The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions

Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from Fei Chen Lab and Evan Macosko! #ToolsOfTheTrade