Happy to share our recent work led by postdoc Dan Corral showing that the maternal adapative immune system promotes optimal lactogenesis. cell.com/cell/abstract/…

Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone. nature.com/articles/s4146…

RORγt+ DCs are key to maintaining intestinal immune balance and preventing inappropriate immune responses to food antigens The Colonna Lab Cell Patrick Rodrigues cell.com/cell/fulltext/…

Excited to share that our work by Patrick Rodrigues and Tong Wu is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more: authors.elsevier.com/sd/article/S00…

Super important work from our colleague and friend, Marco Colonna The Colonna Lab|| Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell cell.com/cell/fulltext/…

latest from our lab: ITACONATE MECHANISM SOLVED!! Tom Paulenda Tomas Paulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages: nature.com/articles/s4225… Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in

Early bird Dendritic cell, Myeloid cell enthusiastic! hurry up Submit your abstract and register soon! poster presentations awards available, amazing talks including: Idoyaga Lab The Colonna Lab Jonathan Kipnis 💔🎗️ @realFlorentGinhoux Dan Kaplan Herbert Strobl Kodi Ravichandran & many others X-less RT

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process.rb.gy/rej77q

Congrats to Ranit Kedmi’s group! RORγt⁺ APCs prime food-specific pTregs and induce oral tolerance. Infection or food poisoning temporarily bypasses this, allowing CD8αβ T cell responses to mimicked food antigens without breaking long-term oral tolerance. nature.com/articles/s4158…

Our new study by Siling Du reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…

🧵1/ Excited to share my first publication from the ColonnaLab in Nature Immunology! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…

Happy to share our latest paper on DC ontogeny! nature.com/articles/s4159… Congratulations to the team and to Dr Zhaoyuan Liu from the Shanghai Institute of Immunology!

I'm excited to share our new study published in Cell. This work uncovers a critical role for dural mast cells in shaping cerebrospinal fluid flow and protecting the brain from infection. cell.com/action/showPdf…

Thrilled to share our new paper in Science Magazine ! We identify septal LYVE1⁺ adipose macrophages (sATMs) as niche signals that control stem cell fate, restrain beiging & shape obesity susceptibility. Team effort with @realFlorentGinhoux and collaborators. science.org/doi/10.1126/sc…

🧵1/8 Happy to share my new preprint “ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.” I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here: researchsquare.com/article/rs-745…

🚨 New preprint! Generative modeling comes to cytometry. Meet CytoVI — a deep generative model from the Yosef Lab & IdoAmitLab for antibody-based single-cell technologies (flow, mass cytometry, CITE-seq). doi.org/10.1101/2025.0… 🧵👇

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

.santosh panda et al. The Colonna Lab WashU Medicine Pathology & Immunology identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. hubs.la/Q03Vr4c90 Do-Hyun Kim Patrick Rodrigues Raki Sudan

Excited to share our new paper in Journal of Experimental Medicine ! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection. 🧵👇1/6 x.com/JExpMed/status…