Had the best time chatting with Daniel Garalde about the fun I've had looking at single-cell isoforms, and as always at the end of the day there's more questions than answers 🧠

Thrilled to share our latest work out now in Science Magazine demonstrating a heterozygote advantage at HLA-II in protecting against lung cancer risk in smokers! Check out Diego Chowell’s tweetorial below👇

Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in Cancer Cell. authors.elsevier.com/c/1ijJ05TA51hO… More details in the thread below.👇 🧵 1/n

The covariance environment defines cellular niches for spatial inference go.nature.com/4auQI72

Our #BICCN paper is out at Nature Neuroscience Led by Anoushka+Wen Hu. Single-cell isoforms across brain regions,development&species. nature.com/articles/s4159… #LongRead #RNA iRNA_COSI #nanopore #pacbio #genomics #Transcripomics #RNAseq #Splicing Thank you Elisa Floriddia !

Researchers use cutting-edge sequencing methods to build the most comprehensive atlas of mRNA variants in the brain. The study, led by Dr. Hagen Tilgner of WCM Brain and Mind Research Institute and Dr. Anoushka Joglekar, may help us better understand brain function and disease. bit.ly/4arHE2P

Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain nature.com/articles/s4159…

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

Fantastic first innovation day at London calling Oxford Nanopore Events. I'd say forgetting to tweet = sign of good times

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In today's Cell, we propose a “developmental constraint” model whereby cancer cell state plasticity is restricted by the organism’s developmental map to access progenitor-like states and differentiated-like states of adjacent lineages.🧵⬇️ sciencedirect.com/science/articl… Ayushi Patel

🧵 Thrilled to share our latest in nature! We’ve mapped fetal blood development in Down syndrome (DS) using single-cell multi-omics, studying why children with DS face a 150-fold higher leukemia risk and blood abnormalities at birth. nature.com/articles/s4158…

Today is the day 🤩. Thrilled to share our nature paper on Th2 function, CAR-T, & 8-year remission!⁩! Huge team effort w/⁦Stephan Grupp MD PhD⁩ ⁦⁦Carl June⁩ ⁦MelenhorstLab⁩ ⁦Li Tang⁩, kudos to my postdoc ⁦Zhiliang⁩ nature.com/articles/s4158…

Beyond thrilled to present our O-MAP—now *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in Nature Genetics with Towfique Raj Panos Roussos Friedman Brain Institute nature.com/articles/s4158…

When your kids ask you what you did to save US science in the crisis of ‘25, you will say that you showed up! Please spread the word and join us!!