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Please check our newest perspective in #EmergTopLifeSci about what sort of chemistry might have supported the emergence and early evolution of life. Prebiotic Chemistry Origins of Life @MRC_LMB emergtoplifesci.org/content/early/…

Harnessing Chemical Energy for the Activation and Joining of Prebiotic Building Blocks Claudia Long-Fei Wu Prebiotic Chemistry doi.org/10.26434/chemr…

Thank you, Paul!

Finally, our work is on Nature Chemistry, @MRC_LMB ISSOL Society Origins of Life @emergenceoflife ,thanks to all the collaborators Liu Ziwei jimmy-mrc Claudia, & David. Paper is here nature.com/articles/s4155…, also a story "behind the paper", chemistrycommunity.nature.com/posts/from-pre…

And finally, all of the prebiotic chemistry-related content, as well as some relevant pieces from our archive, are rounded up on this page: nature.com/collections/ja… Image credit: Ziwei Liu, MRC – Laboratory of Molecular Biology/NASA and NSSDCA

We have found a novel mechanism of choosing α-amino acid among various amine nucleophiles when forming peptide bond in acidic aqueous solution, thanks to the intrinsic chemical property of α-amino acids! Thanks to Liu Ziwei and the boss John. pubs.rsc.org/en/content/art…

This is so cool!

Alkaline lake with bicarbonate and sulfite, shining UV light on, you will expect to get C1 to C4 carboxylate species, including acetate, glycolate,oxalate, malonate and tartrate etc. Completely different mechanism to modern biology of synthesising them!

Available now: 'pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water' by Long-Fei Wu & John D. Sutherland #openaccess 🔓 ⬇️ xlink.rsc.org/?doi=D0CC06042A

Efficient interstrand aminoacyl transfer from an aminoacyl phosphate mixed anhydride at the 5′-terminus of a tRNA acceptor stem mimic to the 2′,3′-diol terminus of a short 3′-overhang pubs.acs.org/doi/10.1021/ja…

Congrats to Jimmy and the Sutherland group. Intriguing role of the volcano gas, SO2, (could be prevailing on early Earth and Mars) again in prebiotic chemistry in generating the letters of life.

As simple as possiple, UV irradiating bicarbonate and bisulfite gives biologically relavent organics in high yielding termed carboxylsulfite chemistry, can it be simpler? Congrats to Liu Ziwei and the collaborators.

Template-Free Assembly of Functional RNAs by Loop-Closing Ligation @MRC_LMB Harvard Chemistry Harvard Medical School MassGeneral Medicine Harvard University #Template #Assembly #RNA #Loop #Closing #Ligation pubs.acs.org/doi/10.1021/ja…

New retrosynthetic strategy is now avalaible when assembling structured, functional RNAs from short pieces Origins of Life @MRC_LMB Thanks all the great collaborators Liu Ziwei Sam Roberts Szostak Lab and John and Meng. pubs.acs.org/doi/10.1021/ja…