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Online Now: Lactate activates the mitochondrial electron transport chain independently of its metabolism dlvr.it/SxtWdP

"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors." One mentor isn’t enough. Learn how Erika Moore built a network of mentors in this #ScienceWorkingLife. scim.ag/4Ep

Review covering aspects of chronic inflammation and HSCs; and interaction between metabolism and inflammation. Nice summary of ISEH webinar Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells - Experimental Hematology exphem.org/article/S0301-…

This is a VERY important message we all need to take to heart as we are designing combination therapies. Is synergy really a priority? Great job, Adam, asking the questions that need to be asked.

Online now! A century of the Warburg effect dlvr.it/Sz8Chw

ARE METABOLIC ENZYMES ON CHROMATIN? Yes, they are ⤵️! We optimized a chromatin enrichment protocol to improve the extraction of chromatin-bound proteins (chromatome) and applied it to > 140 samples, including cancer cell lines and healthy epithelia from 10 different tissues. 🧵

It takes two to think - Itai Yanai & Martin Lercher go.nature.com/3TSOIQK

"We sometimes draw a false equivalence between research advisers and mentors. And while many advisers are excellent mentors, it’s not exactly a prerequisite for running a lab. But it doesn’t have to be that way." #NationalMentoringMonth scim.ag/5Hx Science Careers

"I am discovering that my traits are valuable." In this week's #ScienceWorkingLife, researcher @CGoeyers writes about how she, amid her #PhD struggles, learned she is neurodivergent—and found ways to thrive. scim.ag/609

"..if you leave a meeting with a mentor feeling like your possibilities have narrowed rather than broadened, you know you’ve got the wrong mentor." nejm.org/doi/10.1056/NE…

Super-excited to share our latest work Cell Stem Cell, unraveling the mitochondrial NADPH-cholesterol axis for EV biogenesis, guiding precise HSC fate! Huge congrats to Massimo Massimo BONORA, Claudia Claudia Morganti, and Nick Nick van Gastel! EinsteinSCI bit.ly/48PuICm

Combining clinically relevant STING agonists with BH3-mimetic drugs efficiently kills TRP53/TP53-mutant mouse B lymphoma, human NK/T lymphoma, and acute myeloid leukemia cells Cancer Cell cell.com/cancer-cell/fu…

2021 rejection: “it will never work” 2022 rejection: “it will never work” 2023 rejection: “it will never work” 2024 rejection: “this has already been shown” 😂 nature.com/articles/d4158…

Inhibition of a mutated metabolic enzyme puts the sting back in antitumor immunity News Science Magazine PitarresiPhD Kate Fitzgerald science.org/doi/10.1126/sc… Meng-Ju Wu Rob Manguso science.org/doi/10.1126/sc…

I'm very excited to share the first original research paper of the lab, out now in Experimental Hematology! ISEH de Duve Institute @UCLouvain_be WEL Research Institute Optimization of pre-enrichment strategies for mouse hematopoietic stem... sciencedirect.com/science/articl…

Two posters from our lab at #ISEH2024 today: hernan tirado presents his work on GOT enzymes as metabolic vulnerability in AML (nr 3234), and I present work from Nithya Balasundaram and Ayşegül Erdem on how protein S-acylation allows metabolic flexibility in AML (nr 3004)! ISEH

Manganese boosts NK cell function via cGAS-STING mediated UTX expression onlinelibrary.wiley.com/doi/10.1002/mc…

When my lab members started to leave, I felt like a failure as a mentor | Science | AAAS science.org/content/articl…

Check out the latest #SimplyBlood🩸 post highlighting two Experimental Hematology Young Investigator articles from 2023, which both explore important biological questions in normal and malignant hematopoiesis using murine models. ➡️ simplyblood.org

Take advantage of the opportunity to speak at the Mini Symposium by submitting an abstract by 26 February. Learn how and register today ➡️ iseh.org/2025MiniSympos…