Cell interaction by multiplet sequencing (CIM-seq) by Martin Enge and colleagues is a RNA-seq-based method to analyze physical cell-cell interactions in complex tissues. nature.com/articles/s4159…

Read the News and Views from Dan Wagner here: nature.com/articles/s4159…

I've learned a lot about single-cell pooled CRISPR screens during my postdoc, so I wrote a review with Jenn Sun and Neville Sanjana in Trends in Genetics! Check it out for a history lesson, summaries of current methods, and thoughts on where it's going: sciencedirect.com/science/articl…

Thrilled to announce our latest exploration of CRISPR! By developing an advanced algorithm, we’ve analyzed 8 terabases of microbial data, leading to the discovery of over 200 novel CRISPR systems. Kudos to Han Altae-Tran and Soumya Kannan for their exceptional work! Details in the

Our latest bioRxiv from Chao Zheng & Bastien Hervé et. al. Karolinska Institutet, multioming oligodendroglia at different stages of the EAE mouse model of multiple sclerosis and finding distinct responses of mature oligodendrocytes biorxiv.org/content/10.110…

Xmas present for UCSC users, an R package to easily build Track Hubs. github.com/Novartis/easyT… ps. is there any scientist left in this social network? where is everyone now?

Happy New Year!! Single-Cell Genomics 2024 Gordon Research Conference to be held in the breathtaking Swiss Alps! 🤩🤩🤩 We plan to finalize the program this month. If you are interested in presenting opportunities, please submit your abstracts ASAP! grc.org/single-cell-ge…

The Sandbergs do it again! The synthetic thermostable RNase inhibitor is a fantastic compound and after stringent QC we moved all our scRNAseq/ multiome pipeline to use this component Rickard Sandberg Björn Reinius biorxiv.org/content/10.110…

We are hiring postdoctoral scholars for a very interesting project that involves both basic research on cancer evolution, and a chance to develop methods that will help shape the future of precision medicine! Apply here: ki.varbi.com/en/what:job/jo… ki.varbi.com/se/what:job/jo…

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… Bo Xia

Excited to share our review paper in Cell! With Sasha Gusev Sohini Ramachandran Yang I Li we discuss the genetic and molecular architecture of human traits, future opportunities and challenges and ways forward. authors.elsevier.com/a/1igrbL7PXqPfU

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Júlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110…

The Morris Lab at the Donnelly Centre for Cellular and Biomolecular Research and the University of Toronto is officially open for business, and the lab website is live! Check it out for info on our research and how you can join: morris-lab.org

Looking for a great lab at the cutting edge of human genetics…. Check out Morris Lab!! Unique opportunity with a great mentor at a great place 🚀🚀🚀

Very happy to share our latest work from my postdoc with Lappalainen Lab on recalibrating gene expression changes relative to natural dosage variance: biorxiv.org/content/10.110…

Our latest preprint, Mukund Kabbe's single-cell epigenomics (scATAC & Nano-Cut&Tag) of the adult human central nervous system, finding developmental epigenetic memory at HOX clusters in adult oligodendroglia! Karolinska Institutet biorxiv.org/content/10.110…

We're recruiting postdocs! Join our lab at SciLifeLab KTH Royal Institute of Technology in Stockholm to work on functional genomics at the experimental and/or computational intersection of CRISPR/scRNA-seq/genetics approaches. Close links to our team at NY Genome Center. 1/

We’re recruiting for multiple positions in my lab in New York and Stockholm, at MSc and PhD levels. If you’re interested in pursuing creative systems genetics questions with tools/data like Developmental GTEx, CRISPR and single-cell, please read further / share. 1/

Excited to be presenting at my first #ASHG conference! Hop to session 11-“All the single cells” and learn about the interplay between genetic variants and cellular and molecular aging phenotypes! #ASHG2024

Delighted to share new work from our lab: MultiPerturb-seq 🎛️❌📥📤 Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.