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Great to see this finally out!

Uncovering the causes of disease is one of the greatest challenges in genetics. 🧬 To help advance this, we created AlphaMissense: an AI model classifying missense variants - or genetic changes affecting proteins. Here's how it can help scientists. 🧵 dpmd.ai/alphamissense-…

If you're into cryo-EM/ET and template matching check out our new library, pyTME! Faster ⏩(multi CPU and GPU), flexible, and easy to use! #teamtomo kosinskilab.github.io/pyTME/

Super fast and versatile toolbox for both single-particle #cryoEM and in-situ #teamtomo cryo-ET! Our new pyTME library consolidates particle picking/structure fitting/template matching in a single framework. Preprint: biorxiv.org/content/10.110… Code &howto: github.com/KosinskiLab/py…

I’m incredibly proud to share this joint work by Isomorphic Labs and Google DeepMind on the latest version of AlphaFold, demonstrating SOTA on a wide variety of tasks, including protein-ligand structure, nucleic acids, PPIs, and PTMs.

We are looking for 1 PhD and 1 Postdoc to work on MD simulations of lipid metabolism funded by Swiss National Science Foundation. Interviews will start in Jan. Excellent salary, resources, colleagues and collaborators. Plus the science is great (but I am biased...)! Contact me by email if interested.

Our FreeDTS (software) work finally got published in Nat. Commune. Exciting new features are under development and will be released soon. nature.com/articles/s4146…

Always wanted to run simulations of extracellular matrix, but didn't know where to start? Search no more! Exciting postdoc position Malopolska Centre of Biotechnology UJ in our #dioscuri lab, lots of MD sims, great experimental collabs, and, as always, good coffee ☕️ tinyurl.com/4v5ahkjn Deadline 06.02!

The final version of the PyTME paper published in SoftwareX Journal! PyTME enables fast CPU and GPU-based template matching in #cryoET and fitting in #cryoEM. More in the thread with plenty of screenshots👇 sciencedirect.com/science/articl…

I have an open PhD position. If you are looking for a biomoldeing PhD position, this is for you. candidate.hr-manager.net/ApplicationIni…

Vision Pro is cool and all, but have you ever spent time searching for that format error in your YAML file? Apple just open sourced their new type-safe configuration language Pkl. Define once, and safely render into many formats! pkl-lang.org/blog/introduci… github.com/apple/pkl

Worried about your supercomputer electricity bill⚡️ We got your back! Model your glycans in minutes with #GlycoSHIELD! Amazing collab w/ @cyril_hanus & Shang-Te Danny Hsu, now in Cell tinyurl.com/bdhuzbnu Malopolska Centre of Biotechnology UJ Max Planck Institute of Biophysics Max Planck Society Inserm 中央研究院 Academia Sinica #glycotime

This has been long in the making. Enough for me to have had my fingers in the code back in academia!

Huge congratulations to @DemisHassabis and John Jumper on being awarded the 2024 Nobel Prize in Chemistry for protein structure prediction with #AlphaFold, along with David Baker for computational protein design. This is a monumental achievement for AI, for computational

Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations biorxiv.org/content/10.110… #biorxiv_biophys

New collaborative preprint, Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations. By Valentin J. Maurer Jan Kosinski Marc Siggel biorxiv.org/content/10.110…

Check out our new preprint!🚨 The all-in-one software solution Mosaic which we ship with this preprint now available on github as well! github.com/KosinskiLab/mo…

New method toward modeling cells and viruses! HMFF enables integrative membrane modeling and simulation guided by electron microscopy data. Created by Valentin Maurer and Marc Siggel EMBL Hamburg CSSB, in collaboration with Weria Pezeshkian lab biorxiv.org/content/10.110…