I am pleased to announce that I have updated the online versions of my 2 textbooks (see probml.github.io/pml-book/): I fixed all issues listed on github, added some new references (esp on LLMs), and made a few other small tweaks.

We The Navigation Fund are looking for proposals on how to move scientific publishing into the future. If you think we can do better, stop complaining and come build by applying AI towards open science os.nav.fund/ai-for-os/

Today I have received by email: one disproof of the Riemann hypothesis, one proof that P =/= NP, one proof of the Riemann hypothesis, and one proof that Peano arithmetic is inconsistent (which follows from the two Riemann hypothesis papers, but this was an independent discovery).

Can AI enable safe vaccines at scale that last? Can we anticipate immune response? We tested this .. See cell.com/immunity/fullt… and hms.harvard.edu/news/building-… And big thx to CEPI for funding

Researchers have devised a scheme for painting the edges of a graph that’s *almost* as speedy as possible. Steve Nadis reports: quantamagazine.org/the-fastest-wa…

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Another medical milestone! The first patient treated with a prime edited therapeutic shows positive clinical outcomes consistent with effective rescue of his chronic granulomatous disease (CGD), a debilitating and life-shortening primary immunodeficiency. At least 19 base editing

I am pleased to announce a new version of my RL tutorial. Major update to the LLM chapter (eg DPO, GRPO, thinking), minor updates to the MARL and MBRL chapters and various sections (eg offline RL, DPG, etc). Enjoy! arxiv.org/abs/2412.05265

In Nature Genetics we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14

Our paper on detecting abandoned oil wells with machine learning, led by Pratinav Seth, is accepted at ICML 2025! These wells are a major source of emissions (and groundwater pollution). More details in the thread, and preprint here: arxiv.org/abs/2410.09032

Alzheimer's disease (AD) is associated with numerous proteome changes. We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits. ⬛️ It leads to abnormal accumulation of 20S substrate proteins. biorxiv.org/content/10.110…

Today, we are thrilled to announce that Verve Therapeutics has entered into a definitive agreement to be acquired by Eli Lilly and Company From 2018 to 2025, Verve moved a new concept (a one-dose future for the treatment of atherosclerotic cardiovascular disease) and a new medical technology (in

🥳 Today I was promoted to Senior Lecturer at MIT Math, exactly a decade after my postdoc there. A decade is standard from Lecturer to Principal to Senior. I'm grateful MIT saw the 8 years in genomics, ML, and biotech as an asset. I 🤬 love this job!! 🧑‍🏫🧮 linkedin.com/feed/update/ur…

Digital Bio unlocked spatial NGS in FFPE patient tissues, at scale. Check us out! digit.bio/products

Excited to share some of the work we're doing at Digital Bio to engineer spatially intelligent medicines. Our MxP platform is designed to identify and validate synergistic targets for multifunctional biologics and combination therapies for solid tumors: digit.bio/products.

I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic variant embeddings to downstream tasks in human genetics. This work was led by the amazing Divyanshi Srivastava! biorxiv.org/content/10.110…

Teenager Hannah Cairo's recent proof of a major problem in harmonic analysis is the most amazing—and moving—story I've covered in more than a decade as a math journalist.

Scaling DNA sequencing is a notable success story. Scaling protein analysis is harder since the proteome is a much taller mountain: nature.com/articles/s4159… Asimov Press writes about Parallel Squared Technology Institute (PTI)'s approach to scale up proteomics.

My resignation letter from CDC. Dear Dr. Houry, I am writing to formally resign from my position as Director of the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC), effective August 28, 2025, close of business.