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The coolest things in the world are n=1 things. Art that no one else can replicate. Companies that no one else would dare to build. Ambitions that no one else would dare to think of. Asks that no one else would dare to make. Groups of people that no one else can assemble. Poems

List of biotech founders and drug hunters who were unlikely to succeed (and yet they did) ladanuzhna.xyz/writing/list-o… So many of outlier-impressive outcomes in biotech came from people who had odds stacked against them. Have been keeping this list to myself for some time now, but

Exciting new research shows retrotransposons, ancient viruses making up ~1/2 our DNA, can create precise biological clocks to measure our rate of aging. This is the tip of the iceberg… 🧵

Your body has its own renewal system. We call it sleep, and the more you learn to respect it, by giving it 7-8 hours to do its thing every night, the slower your aging clock will tick, both physically and mentally

Sleep is your #1 life priority. Fight for it as hard as anything else you do in life.

Restricting calories by 12% significantly slows the rate of human aging 🥗⏰ 🧵 nature.com/articles/s4358…

First atlas of nasal/oral microbes during aging. Before the ages of 15-24, youths have fewer species than older people & microbe types are influenced by smoking, infections, antibiotics & living with children. Your mouth is more important than you think. Here's why...

Sammy Basso Sammy Basso, one of the most remarkable people to share our world, passed away last night from complications associated with progeria, the ultra-rare ‘rapid aging’ genetic disease Sammy both suffered from and transcended. Sammy realized that a base editing treatment

Survivor of rare rapid-ageing disease progeria dies at 28 | Reuters reuters.com/world/europe/s…

Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates Read this #OpenAccess Research Article by Dina Rekler, Shai Ofek, Sarah Kagan, Gilgi Friedlander & Chaya Kalcheim Hebrew University: journals.biologists.com/dev/article/15…

New nature A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells nature.com/articles/s4158… Ferdinand von Meyenn Laura Hinte

My lab’s new paper using chromosome engineering to correct a complex chromosomal rearrangement is now up on bioRxiv! biorxiv.org/content/10.110…

Science is the belief in the ignorance of experts. Never accept an idea just because someone with a title says it’s true.

A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with Jane Kondev Rob Phillips Hernan Garcia. 20 years later we can measure them: nature.com/articles/s4158… Thank you William J. Greenleaf Benjamin Doughty Michaela Hinks Julia and all co-authors!

MDL-800, a chemical activator the NAD+-dependent enzyme SIRT6, which is linked to mouse & human longevity, increases the degradation of toxic amyloid precursor protein (APP) & delays dementia in Alzheimer’s model mice 🐁🧠💪 science.org/doi/10.1126/sc…

qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification. biorxiv.org/content/10.110…