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Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.

The Cell Science Annual Meeting welcomed over 250 grantees + partners to discuss new #tech that will help discover biological insights, updates to the Human Cell Atlas & the potential of synthetic biology to illuminate cellular complexity.

It is finally out! I am incredibly proud to share that my work has officially been published in Cell Cell! This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Jarosz Lab Stanford Medicine cell.com/cell/fulltext/…

Alternative splicing (AS) is common, but its impact on the proteome remains debated, especially in primary cells. What determines which AS isoforms are translated and result in abundant proteins ? We find that proteoform-specific ... 🧵 biorxiv.org/content/10.110…

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great department with world-class expertise in all sorts of biomedical & biological engineering topics, including synthetic biology. 🇬🇧imperial.ac.uk/jobs/search-jo…

New pre-print: biorxiv.org/content/10.110… In collaboration with Mo Khalil, we develop AnEVO, a version of eVOLVER for benchtop anaerobic work and gas fermentation, and use it to study co-metabolism in E. limosum. Included parts list makes it easy to duplicate in your own lab!

(1/n) New preprint from clarice Fan Fang Varshini Ramanathan in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…

Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single nucleosomes are responsible for A and B compartments in cell nucleus.

Read the full preprint below 👇 If you're interested in the interface of bioengineering, DNA and virtual cell foundation models, and agentic reasoning, shoot me a note. We're hiring postdocs and ML researchers and starting some crazy new projects biorxiv.org/content/10.110…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

I wrote an Op-Ed about the government's attacks on Harvard. Please share with anybody who thinks these attacks help anybody. prosyn.org/PhWi74r?h=KyJ1…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…