
Mohammad Jafari
@mmj_cryoem
Senior scientist @pmcancercentre and Associate professor @UofT. Interested in cryoEM and structural biology.
ID: 954179890374463488
19-01-2018 02:33:08
79 Tweet
174 Followers
135 Following

Ammonium acetate does not buffer at neutral pH, but we have no better option for native MS. But what if I told you we've uncovered an alternative? doi.org/10.1021/acs.an… By extraordinaire PhD student, Brad Davis MCB at UofG ACS for Authors ACS Analytical Chemistry Journals Advancing Mass Spectrometry Native MS-Guided Structural Biology Center


Fungal fatty acid synthases are key drug targets against opportunistic infections affecting immunocompromised patients. Our team, led by Elnaz Khalili Samani, has developed a protein engineering strategy to delve into the complex mechanisms of these synthases. rdcu.be/dvRmQ


Presenting my work today Biophysical Society annual meeting in the Protein Structure and Conformation platform as flash talk and on Wednesday in the poster session. #bps2024






An exciting study lead by talented PhD student Elnaz Khalili Samani revealed cryoEM structures of native protein assemblies from brain lysate of a rat model of Alzheimer's disease. Collaboration with JoAnne McLaurin and Thomas Kislinger. doi.org/10.1101/2024.0…

Last weekend I had the pleasure to attending the Walk to Conquer the Cancer hosted by the The Princess Margaret Cancer Foundation Enjoyed showing DNA extraction to the participants.


1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 Chimerix, Inc. Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts


Happy to share our little discovery with Simone Mattei team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out Nature Communications! A collaboration between @medicineUVA, @EMBL, EMBL Imaging Centre, MEMC. Congrats to all authors! nature.com/articles/s4146…



Excited to see this work published. A great collaboration between multidisciplinary research groups driven by talented PhD student Elnaz Khalili Samani

Latest work from our group by Elnaz Khalili Samani We used Build and Retrieve (BaR) method to reconstruct cryoEM maps from crude protein purification sourced from Alzheimer’s disease model rat brain.


Protein scavenger inspires new drug design✨ Scientists unveiled an essential protein degradation process in mitochondria, offering new ideas to curb cancer cells’ energy supply. A study in pnas led by Drs. Aaron Schimmer University Health Network and Siavash Vahidi University of Guelph. pnas.org/doi/10.1073/pn…


How exanctly does lipid-siRNA organization control the intracellular dynamics of LNPs? Our latest J. Am. Chem. Soc. article provides insights on the link between LNP internal structure and its intracellular delivery profiles. 🧬 Gang Zheng Gang Zheng Lab pubs.acs.org/doi/10.1021/ja…
