Important study. Our work in bioRxiv provides the molecular underpinnings - how the SARS-CoV-2 spike protein induces vascular damage and inflammation in the skull-meninges-brain axis. biorxiv.org/content/10.110…

Great opportunity to collaborate! Check out the interactive database at becaging.de

The April issue is live nature.com/nbt/volumes/42… Our cover shows an image of a whole mouse body with depth color-coding of a neuronal marker. Mai et al. present wildDISCO, a method for whole-body imaging compatible with standard IgG antibody labeling go.nature.com/3PXs1Zw

Amazing case of combining virtual reality for scientific and broad use! Honored to be part of this effort :)

The DELiVR pipeline enables deep learning-based analysis of neuronal activity or other processes in the brain after tissue clearing and light-sheet imaging. DELiVR’s virtual reality approach facilitates the generation of training data for deep learning. nature.com/articles/s4159…

DELiVR, is a deep-learning pipeline for whole-brain cell mapping, which is trained on reference annotations generated in a virtual reality environment. nature.com/articles/s4159… #NBThighlight

New preprint on cortex folding, by an international team around Ruediger Klein: biorxiv.org/content/10.110…

🎉We're thrilled to announce the #MICCAI2024 SELMA challenge on self-supervised learning for 3D light-sheet microscopy image segmentation. Explore our dataset, which contains 3D light-sheet microscopy images of various labeled structures and is possibly the largest 3D microscopy

The July issue is live today! nature.com/nmeth/volumes/… The beautiful cover comes from the Ali Max Erturk and shows c-Fos+ neuronal mapping in whole mouse brains. See paper: nature.com/articles/s4159…

What if we could map every cell in the body, revealing its location and molecular identity? In this @NatureMethods perspective, we discuss the new era of 3D-omics by tissue clearing and AI, called Deep 3D Histology: rdcu.be/dNBe8 PDF: bit.ly/3WaD0QU 🧵👇🏼

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵biorxiv.org/content/10.110…

Thrilled to announce that I will be starting as an Assistant Professor at Cornell University in February! #MICCAI #miccai2024 linkedin.com/posts/johannes…

ErtürkLab is now on BlueSky! 🦋 We’re exploring new spaces for science communication. Follow us for our updates on AI & tissue clearing-driven whole body imaging for cellular-level disease research: bsky.app/profile/erturk…

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵👇Cell Host & Microbe cell.com/cell-host-micr…

SCP-Nano: Advancing Precision Medicine with Nanocarrier Visualization How can life-saving therapies reach their target cells without harmful side effects? 👉t1p.de/muluc 💡Researchers at #HelmholtzMunich, Universität München, and TU München have developed SCP-Nano

LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in Nature Biotechnology: an AI-based technology for precision nanotechnology. nature.com/articles/s4158…

See our recent Nature Biotechnology study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s4158…

Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s4146…

We have developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. MouseMapper uncovered obesity-induced

We discovered that the skull bone marrow has direct connections to brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies. Kolabas…Ertürk, Cell: cell.com/cell/pdf/S0092… biorxiv.org/content/10.110… bit.ly/3PQuymm