Nov. Featured Article: Spatial profiling reveals expression patterns and smooth muscle cell plasticity linked to human coronary plaque instability ahajrnls.org/4hoW9IM

New study reveals that exhausted CD8+ T cells upregulate lactate transporter MCT11, in the tumor microenvironment. Blocking MCT11 improves T cell function and reduces tumor growth in mice, offering a potential new cancer immunotherapy target. #Lactate nature.com/articles/s4159…

“Good morning, Birmingham! ❄️

Excited to share our latest publication! We uncover how CARKL, a key enzyme in the PPP, reshapes T cell metabolism, affecting respiration, ATP, cytokines, and migration. Insights into immune regulation and potential therapies! #Immunometabolism #TCells academic.oup.com/discovimmunolo…

Rheumatoid arthritis is driven by metabolic rewiring: T cells & macrophages adapt to glucose-deprived joints, fueling inflammation via glutamine use and mitochondrial dysfunction. A must-read on how cellular metabolism shapes RA pathology! sciencedirect.com/science/articl…

New study reveals dendritic cell roles in rheumatoid arthritis: inflammatory DC3s drive synovitis, while tolerogenic DC2s are lost. Targeting DC3s or restoring DC2s could transform RA treatment. A groundbreaking read for immune therapy research! cell.com/immunity/fullt…

Explore metabolic regulators of T cell migration with 𝘔𝘪𝘤𝘩𝘦𝘭𝘢𝘯𝘨𝘦𝘭𝘰 𝘊𝘦𝘳𝘵𝘰 Claudio Mauro et al. Uni of Birmingham in December's Outstanding Article from Discovery Immunology Journal academic.oup.com/discovimmunolo…

Activating PKM2 in macrophages boosts IL-10 production via glycolytic ATP, converted to adenosine signaling through A2a receptors. This links glycolysis to anti-inflammatory responses and improves mitochondrial health. sciencedirect.com/science/articl…

Super proud of our own Jordesh and Atrayee for presenting their research updates at today’s Inflammation and Ageing seminar! Fantastic work and great discussions. Well done! #Research #Teamwork

Those who shout the loudest and threaten the most often do so to mask their own powerlessness. Strength doesn’t need to intimidate, it speaks for itself. #Trump et al.

🔥 New study: In inflamed skin, Treg cells expressing SSAT lose their suppressive function & shift to a TH17-like state, driven by 4-1BBL+ keratinocytes. Blocking SSAT restores Treg function, offering a targeted therapy for chronic skin inflammation! cell.com/immunity/fullt…

I found this review extremely informative and highly recommend reading it! It provides a comprehensive overview of energy metabolism, its role in health and disease, and emerging therapeutic strategies. #metabolism nature.com/articles/s4139…

Jannik Sinner is the Wimbledon champion! 🏆🔥 From prodigy to star, he conquers the grass and secures his place in history. The future is now. 🇮🇹🎾 #Wimbledon #Sinner #ChampionsRise

Thank you to Discovery Immunology Journal for highlighting our paper and sharing it on social media! We appreciate the support and hope readers enjoy exploring our work. #Immunology #immunometabolism Inflammation and Ageing UoB School of Infection, Inflammation & Immunology

🚨 New paper out Nature Metabolism! We show that lactate drives ectopic lymphoid structures in Sjögren’s disease, and blocking SLC5A12 with our mAb 3C7 disrupts inflammation at its core. 🔗 nature.com/articles/s4225… Uni of Birmingham College of Medicine and Health (UoB) UoB School of Infection, Inflammation & Immunology UniBirmingham News

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution go.nature.com/4miXXoV

Excited to share my piece on Springer Nature Research Communities: “Uncovering a metabolic checkpoint in autoimmune inflammation: how lactate shapes immune hotspots”, based on my latest Nature Metabolism paper. Read 👉 communities.springernature.com/posts/uncoveri… UoB School of Infection, Inflammation & Immunology Inflammation and Ageing