Matthäus Felsenstein (@mattfelsenstein) 's Twitter Profile
Matthäus Felsenstein

@mattfelsenstein

Surgical Oncologist @ChariteBerlin | Fellow Pancreatic Surgery | Clinician Scientist @berlinnovation | Experimental oncology @Sauer_et_al

ID: 1185803755406663680

linkhttps://www.experimental-surgery.de/Projects/molecular_carcinogenesis/ calendar_today20-10-2019 06:23:59

31 Tweet

28 Followers

47 Following

Marco Del Chiaro (@chiaro_del) 's Twitter Profile Photo

Neoadjuvant Chemotherapy versus Upfront Surgery for Resectable Pancreatic Adenocarcinoma: An Updated Nationwide Stu… pubmed.ncbi.nlm.nih.gov/37226812/ Is neo adjuvant treatment preferable to upfront surgery for resectable pancreatic cancer? CUpancreas CU Surgical Oncology CU Cancer Center

Marc Besselink (@marcbesselink) 's Twitter Profile Photo

#NorPACT1 results #ASCO23: #neoadjuvant tx did NOT ⛔️ improve survival in resectable #PancreaticCancer #PREOPANC3 🇳🇱DPCG Bas Groot Koerkamp well underway!! Congrats to study team Knut Jørgen Labori 🇳🇴. Looking forward to discuss #EAHPBA23 E-AHPBA IHPBA Protocol

Marc Besselink (@marcbesselink) 's Twitter Profile Photo

Is #robotic, #laparoscopic distal pancreatectomy safe for resectable #PancreaticCancer? Final results European E-MIPS #DIPLOMA trial presented #EAHPBA2023 Mohamed Abu Hilal: 258pts randomised to MIS vs open: ✅non-inferiority for R0 resection was met. Small benefits for MIS but

Is #robotic, #laparoscopic distal pancreatectomy safe for resectable #PancreaticCancer? 

Final results European <a href="/e_mips/">E-MIPS</a> #DIPLOMA trial presented #EAHPBA2023 <a href="/Abuhilal9Abu/">Mohamed Abu Hilal</a>: 258pts randomised to MIS vs open: ✅non-inferiority for R0 resection was met. 

Small benefits for MIS but
Marc Besselink (@marcbesselink) 's Twitter Profile Photo

Teaser #PREOPANC2 design & accrual: Total #Neoadjuvant #FOLFIRINOX in resectable + borderline resect #PancreaticCancer vs “winning arm” #PREOPANC trial #EAHPBA2023: accrual faster than planned ✅, final survival outcome expected in Sept 2023 ✅ @EmmelieDekker Bas Groot Koerkamp

Teaser #PREOPANC2 design &amp; accrual: Total #Neoadjuvant #FOLFIRINOX in resectable + borderline resect #PancreaticCancer vs “winning arm” #PREOPANC trial #EAHPBA2023: accrual faster than planned ✅, final survival outcome expected in Sept 2023 ✅ 
@EmmelieDekker <a href="/BasGrootKoerkam/">Bas Groot Koerkamp</a>
Notta Lab (@labnotta) 's Twitter Profile Photo

Our team, led by Jaeseung Kim has just published a paper in Nature Genetics We uncovered 3 novel transcriptomic subtypes in BCR-ABL1 leukemia with significant clinical implications. Read Jae’s Tweetorial below. #Leukemia #PrecisionMedicine Ontario Institute for Cancer Research (OICR) UHN Research

Ray Paranal (@rayparanal) 's Twitter Profile Photo

Extremely excited to share our most recent work! We investigated ATM mutations in the context of pancreatic precursor lesions and pancreatic adenocarcinomas. We found that somatic loss of ATM is a late event in pancreatic tumorigenesis. …thsocjournals.onlinelibrary.wiley.com/share/RDIPSNIE…

JorgKleeff (@jorgkleeff) 's Twitter Profile Photo

3rd Meeting West-East Balkan Chapter E-AHPBA & 4th Meeting Serbian Pancreatic Club - great meeting and organization, honor and pleasure to participate! Thanks Dejan Radenkovic

3rd Meeting West-East Balkan Chapter <a href="/EAHPBA/">E-AHPBA</a> &amp; 4th Meeting Serbian Pancreatic Club - great meeting and organization, honor and pleasure to participate! Thanks <a href="/DejanRadenkovi2/">Dejan Radenkovic</a>
Giovanni Marchegiani (@gio_marchegiani) 's Twitter Profile Photo

Strategies to prevent / mitigate 🚒 post-pancreatectomy hemorrhage (PPH) 🔥 🧑‍🚒 Review of 99 RCT revealed to 👇 PPH Intraop: PJ, 🫔 GDA wrap, small jej incision of PJ Postop: Pasireotide 💉 and algorithm-based 🧮 management 😱 NO RCT on PPH treatment! journals.lww.com/international-…

Strategies to prevent / mitigate 🚒 post-pancreatectomy hemorrhage (PPH) 🔥

🧑‍🚒 Review of 99 RCT revealed to 👇 PPH

Intraop: PJ, 🫔 GDA wrap, small jej incision of PJ
Postop: Pasireotide 💉 and algorithm-based 🧮
 management

😱 NO RCT on PPH treatment!

journals.lww.com/international-…
Giovanni Marchegiani (@gio_marchegiani) 's Twitter Profile Photo

Large-scale pancreatic cancer detection via non-contrast CT and deep learning ☢️ (PANDA) 🤖 The future of screening is here? 🐼 validated on 6k patients outperformed mean radiologist by 34% sensitivity and 6% specificity for PDAC identification 🦾 nature.com/articles/s4159…

Large-scale pancreatic cancer detection via non-contrast CT and deep learning ☢️ (PANDA)

🤖 The future of screening is here? 

🐼 validated on 6k patients outperformed mean radiologist by 34% sensitivity and 6% specificity for PDAC identification

🦾 nature.com/articles/s4159…
Marc Besselink (@marcbesselink) 's Twitter Profile Photo

Outcome of #Pancreatoduodenectomy in 1,402 pts 🇳🇱 with ISGPS-D?? = soft texture & pancreatic duct ≤3 mm Overall: ✅4.1% in-hospital mortality ✅45.9% major morbidity, In the 30% pts who develop POPF: ⚠️ Mortality 6.3% vs. 3.5%; P=0.016 ⚠️ Major morb 88% vs. 28% P<0.001 Take

Pancreas Verona (@pancreasverona) 's Twitter Profile Photo

New guidelines for IPMN management, formulated by an expert group including our Roberto Salvia. Major changes: 🟢Imaging findings and cytology obtained by EUS included into the assessment of HRS and WF 🟢Surveillance discontinuation possibile for small unchanged BD-IPMN after 5years

New guidelines for IPMN management, formulated by an expert group including our <a href="/SalviaRobi/">Roberto Salvia</a>. Major changes:
🟢Imaging findings and cytology obtained by EUS included into the assessment of HRS and WF
🟢Surveillance discontinuation possibile for small unchanged BD-IPMN after 5years
Marc Besselink (@marcbesselink) 's Twitter Profile Photo

Can one randomize all patients with #PancreaticCancer in a single country 🇳🇱 in a stepped-wedge RCT to improve guideline-based care? Yes✅ #PACAP1 Did this improve treatment nationwide? Yes, partially✅ Did this improve survival? No⛔️ 🔑 Why? 61% of 5800+ patients received no

Can one randomize all patients with #PancreaticCancer in a single country 🇳🇱 in a stepped-wedge RCT to improve guideline-based care? Yes✅ #PACAP1

Did this improve treatment nationwide? Yes, partially✅ 

Did this improve survival? No⛔️

🔑 Why? 61% of 5800+ patients received no
nature (@nature) 's Twitter Profile Photo

Nature research paper: 3D genomic mapping reveals multifocality of human pancreatic precancers go.nature.com/3QnldUH

Marc Besselink (@marcbesselink) 's Twitter Profile Photo

🚀 #DIPLOMA2 international RCT MIS vs open #Whipple: 1st ever presentation! 🔑 288 pts randomized (2:1) in 14 high volume European centers, 90% robot E-MIPS #IHPBA24 Mohamed Abu Hilal Anouk Emmen Nine de Graaf ⏩️Primary endpoint (non-inferiority): no differences in CCI

🚀 #DIPLOMA2 international RCT MIS vs open #Whipple: 1st ever presentation!
🔑 288 pts randomized (2:1) in 14 high volume European centers, 90% robot <a href="/e_mips/">E-MIPS</a> #IHPBA24 <a href="/Abuhilal9Abu/">Mohamed Abu Hilal</a> <a href="/AnoukEmmen/">Anouk Emmen</a> <a href="/nine_degraaf/">Nine de Graaf</a> 
⏩️Primary endpoint (non-inferiority): no differences in CCI