Exceptional #2photon #fluorescence #imaging by Oleg Zhukov Oleg Zhukov from Martin Lauritzen Lab. You are looking at #adsorptive -mediated #transcytosis across the #bloodbrainbarrier in the #mouse #brain in #realtime #invivo. Perfect entry for a #FluorescenceFriday

Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease | Nature Neuroscience nature.com/articles/s4159…

.Caltech researchers including Dr. Viviana Gradinaru and Xinhong Chen evolved AAV9 capsids into vectors that transduce brain #endothelial cells following systemic administration in wild-type mice and rats. 🐁 🐀 Learn more about their research: 👉 go.nature.com/3N8HQtk

REVIEW|Aitken et al. discuss the current understanding of how #endothelial cells sense #BloodFlow focusing on #mechanosensing and #mechanotransduction molecules and mechanisms. Tzima Lab Vedanta Mehta, RDM Oxford, British Heart Foundation| nature.com/articles/s4416… 👉rdcu.be/deDgu

What's the biggest mistake that I see pre-tenure assistant professors making? It looks like this: #AcademicTwitter #TenureTrack #AssistantProfessor #OnTrackforTenure

LiddelowLab presentation in 30 minutes! I'll be giving a keynote about our decade-long goal to uncover reactive astrocyte sub-state functions. #Euroglia #glia2023 #gliameeting

Human iPSC-derived brain #pericytes can replace lost pericytes - forming hybrid microvessels - and repair #BBB leaks in the living mouse brain! Is cell therapy the future of medicine for pericyte-deficient neurological disorders? Happy to see it out! biorxiv.org/content/10.110…

Delighted to share our take on the pivotal role of #vasculature in #adipose tissue biology in both health & disease: rdcu.be/dmYbb Nature Reviews Endocrinology. Heartfelt thanks to Ibrahim AlZaim, Laura de Rooij, borgeson lab, & Bilal Sheikh for their invaluable contributions!✨

Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo | Journal of Neuroinflammation | Full Text jneuroinflammation.biomedcentral.com/articles/10.11…

Financial Times opinion writer weighs in on my Zlokovic investigation and related matters - 'There is a scientific fraud epidemic — and we are ignoring the cure' ft.com/content/c88634… via @ft Anjana Ahuja

Anyone having luck using the acetylcholine sensor iAchSnFR in mice in vivo?

What would we be without collaterals….Very proud to share this. Big thanks to Nadine and Mohamad for amazing efforts+ all collaborators. Mohamad Amki Swiss National Science Foundation Unispital_USZ Universität Zürich Tanter Mickael Franca Schmid Institute of Pharmacology and Toxicology

Jeg har nu blokeret Svinemosevej. Jeg flytter mig ikke før, vi får en CO2 afgift på landbruget!🙂 #dkpol #godweekend

1/ 🔥 Exciting findings from our collaboration between University of Tasmania, @SeattleChildrens, and University of Copenhagen! We've discovered a new way #microglia interact with 🧠 vasculature, which could reshape our understanding of their role in #brain health and disease. 🧵 biorxiv.org/content/10.110…

2/ Using the extensive 🐭 🧠#MICrONS Cortical MM^3 #ElectronMicroscopy dataset by Allen Institute, we found that about 20% of #microglia form direct contacts with #bloodvessels, bypassing the #astrocyteendfeet layer. We termed these contact points “plugs”. microns-explorer.org/cortical-mm3

Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes | Circulation Research ahajournals.org/doi/full/10.11…

The #TinyBrainsEU satellite workshop inaugurates this week's Mindlab course at ICFO! Jennifer Lynch and Martin Lauritzen gave two keynote talks on diffuse optics for neuroprotection in congenital heart disease and transport regulation at the blood-brain barrier.

The brain continuously generates metabolic water by glucose oxidation via mitochondrial activity in neurons This water contributes to brain fluid homeostasis, supporting nutrient transport and waste clearance. fluidsbarrierscns.biomedcentral.com/articles/10.11…

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧵