Among 15,979 New England healthcare biobank participants with persistently normal SBP, cumulative elevated (≥80 mmHg) DBP burden associated with MACE across all age/sex/race Pradeep Natarajan Shriie Ganesh Art Schuermans Satoshi Koyama 『S』... Hokyou Lee, MD, PhD, FAHA Michael Honigberg, MD, MPP ahajrnls.org/3Oj4sbY

Excited to share AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in nature nature.com/articles/s4158…

Genetic variation across and within individuals go.nature.com/3PFrsTf #Review by Zhi Yu, Tim Coorens, Md Mesbah Uddin, Kristin G. Ardlie, Niall J Lennon & Pradeep Natarajan

Very excited to share our review on genetic variation across and within individuals led by Zhi Yu Tim Coorens! nature.com/articles/s4157… Nature Reviews Genetics

Pleiotropy, epistasis and the genetic architecture of quantitative traits go.nature.com/3VK75YZ #Review by Trudy Mackay and Robert Anholt Clemson University College of Science Clemson Center for Human Genetics

🔥 Hiring a funded postdoctoral fellow position in human genetics! Come join us CGM at MGH Broad Institute Harvard Medical School! 🔥 Apply: partners.taleo.net/careersection/…

Online now!✨RESEARCH: Tara Mack, Michael Raddatz and colleagues use the PACER method to quantify rates of hematopoietic clonal expansion, identifying epigenetic and proteomic patterns associated with CHIP Alex Bick nature.com/articles/s4358… rdcu.be/dJUSs

🚨 Now recruiting a postdoctoral research fellow to join us @ the MGH Cardiovascular Research Center Mass General Heart + Broad Institute! Interested in applying genetics 🧬 / multi-omics 🧪 at the intersection of cardiovascular 🫀, reproductive 🤰, and aging 🧓 biology? Apply here: partners.taleo.net/careersection/…

.Michael Honigberg, MD, MPP is a *phenomenal* mentor. Highly recommend 👇

LDAK-KVIK is our new tool for mixed-model association analysis (MMAA) of quantitative and binary phenotypes. LDAK-KVIK has the power of BOLT-LMM, but the computational demands of REGENIE. Read more in our Medrxiv Preprint medrxiv.org/content/10.110… or in the tweets below.

15 years of innovation: Mass General Brigham Biobank data helps researchers identify genetic predispositions to heart disease and more, offering a better chance of helping patients before they experience symptoms. spklr.io/6011sHch

Prevention requires bold & forward-thinking investments. My OpEd on why letting funding lapse for AllofUsResearch would be a step backwards statnews.com/2024/09/03/all… STAT

Our study led by M Mesbah Uddin & with Christie Ballantyne uses longitudinal blood-based exome sequencing over median 21y to discover & characterize features of clonal dynamics. nature.com/articles/s4146… Nature Communications

Terrific work led by M Mesbah Uddin along with Mohammad Saadatagah Pradeep Natarajan #ARIC investigators and other colleagues taking advantage of long term follow up Kudos to M Mesbah Uddin to get this to the finish line, team science + great individual effort

Alex Reiner Fred Hutch Cancer Center, Alex Bick, and I are excited to share our new preprint, “Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women” doi.org/10.1101/2025.0… 1/n

Mosaic loss of Y chromosome portends a high risk of mortality after coronary angiography. Read more in #EHJ 👉 bit.ly/4aU5upd Rocco Montone EHJ Editor-in-Chief

Very cool work by Rahul Gupta NealeLab /labneale.bsky.social Vamsi Mootha, and delighted to contribute. Super cool new connections between mtDNA mutational burden in blood & clonal hematopoiesis 👇

Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity medrxiv.org/content/10.110…

The lab's first sim pub of #ESC2025 is now online in JACC Journals #JACC ! jacc.org/doi/10.1016/j.… Led by 🇧🇪⭐️ Daniel Ezzat , we examined clonal hematopoiesis (CHIP) 🩸 & cardiovascular 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the Women's Health Initiative (WHI) Study 👇 (1/X)

Does clonal hematopoiesis of indeterminate potential (CHIP) predict heart inflammation? Thrilled to share our work identifying CHIP as a risk factor for myo-/pericarditis, with the amazing Michael Honigberg, MD, MPP Simultaneous pub with #ESC2025 in JAMA Cardiology jamanetwork.com/journals/jamac… (1/x)