Kim, Murphy et al. Test Account show that tumor-derived IL-6 blocks development of type 1 classical #DendriticCells by inducing C/EBPβ in the common DC progenitor, which supports Zeb2 expression in the −165 kb enhancer, thus preventing pre-cDC1 specification bit.ly/3D4yOcx

Very interesting paper from the Singer lab proposing “clonal eviction” of autoreactive thymocytes as a mechanism for CD8 T cell central tolerance.

Please distribute 2024 flyer!

🚨Dendritic cell lovers!🚨 Mark in your calendar the 17th International symposium on DCs in #DC2024Barcelona (20-23 October 2024). Please, check the webpage dc2024barcelona.com with the preliminary program! Thanks to our fantastic speakers for accepting the invitation! 👇🏻👇🏻👇🏻

After decades of frustration and failed attempts, scientists might finally be on the cusp of developing therapies to restore immune ‘tolerance’ in conditions such as diabetes, lupus & multiple sclerosis. @nature nature.com/articles/d4158…

A look back at #immunology in Science Magazine in January '24. ⚫️Antibody production is supported by tRNA wobble. ⚫️Signs of immune complement dysregulation in Long COVID. ⚫️Age-associated B cells depend on the transcription factor ZEB2. Links follow⬇️

By the way, MLB, re: the games that were on Bally and now unavailable to so many folks, lift the damn blackout of those games for those who pay $120 or $140 for MLB.TV. To continue to black those out is horrendous.

For the love of God people just do some experiments, enough with the single cell seq atlases

new CD8 T cell subset?

Congrats Patrick Rodrigues! Distinct lineages contribute to cDC2 diversity: lymphoid-derived pDC-like and myeloid-derived pre-cDC2 both develop into transcriptionally similar cDC2, crucial for humoral immune responses, and are distinct from pro-DC3 derived DC3. twtr.to/Tr5-h

Meet the keynote speaker for day one at #CFM_Immunomodulation: Kenneth Murphy from @WUSTL will speak about 'Development and function of the cDC1' 🤝With the support of CaixaResearch. 🔗cnio.es/eventos/fronti…

Goodness

Spencer Strider when he has to face the Philadelphia Phillies

So cool to see our recent publication in Journal of Experimental Medicine from Haldar Lab @ Penn PennSurgery Penn Medicine and MD Anderson Cancer Center characterizing a unique population of immunosuppressive iron-rich TAMs highlighted in this month's Science Magazine - science.org/doi/10.1126/sc….

#ICYMI Learn about mechanisms that bridge #ImmuneSystem arms in this special collection guest edited by Dr. Sebastian Joyce. It highlights the complex #ImmuneCircuits #ImmuneEcosystems that impact innate & adaptive immunity. ➡️ ow.ly/ZynL50SCpXb #ReadTheJI #ILCs

search.app/2VMcBRRSnqvDaw…

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

#Immunology out now Science Magazine After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/lCPsea3 By Jobinet al.

Early bird Dendritic cell, Myeloid cell enthusiastic! hurry up Submit your abstract and register soon! poster presentations awards available, amazing talks including: Idoyaga Lab The Colonna Lab Jonathan Kipnis 💔🎗️ @realFlorentGinhoux Dan Kaplan Herbert Strobl Kodi Ravichandran & many others X-less RT

We are hiring! Please help spread the words. Thank you! nature.com/naturecareers/…