Patho-DBiT, for the first time, maps spatial distribution of microRNAs in clinically archived FFPE tissues and reveals their regulatory roles in tumorigenesis! #NobelPrize2024

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have

Glad to share the peer-reviewed version of the Matthew G. Heffel manuscript now in nature. In collaboration with Paredes Lab , we studied the chromatin conformation and DNA methylation changes during human hippocampus and frontal cortex development. nature.com/articles/s4158…

REVIEW npj Journals Systems immunology approaches to study T cells in health and disease nature.com/articles/s4154…

NEW content online! Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells go.nature.com/3YkwcCs

Here comes our new Cancer Cell review on #hallmarks of #cancer #immune escape. Introducing the new framework of the #3Cs! kudos to Claudia Galassi, PhD and Ilio Vitale for doing the heavy lifting. Thanks to Timothy Chan for input!!

Excited to share our work out today in Immunity on tumor associated macrophages in pediatric high-grade gliomas! Many thanks to my co-first authors, my mentor The Hambardzumyan Lab , our collaborators, reviewers, and editors who made this possible. 🧠 sciencedirect.com/science/articl…

Online Now: The hallmarks of cancer immune evasion dlvr.it/TFFy1H

Happy to share our recent review ⁦Trends in Cancer⁩ led by co-first authors from our lab Santiago Haase & Stephen Carney, discussing the Epigenetic landscape in pediatric gliomas & new therapeutic opportunities ⁦Michigan Neurosurgery⁩ ⁦Michigan Medicine⁩ pubmed.ncbi.nlm.nih.gov/39394009/

The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution biorxiv.org/cgi/content/sh… #biorxiv_cancer

I wanted to share my perspective/review article regarding epigenetics research in evolutionary biology. I had a lot of fun thinking about where the field is and where we are going. I hope you enjoy! academic.oup.com/mbe/article/41…

LINE1 modulate human T cell function by regulating protein synthesis during the life span science.org/doi/10.1126/sc…

♨️ Defining genome access of transcription factors Petra Gross, Nature Genetics (Oct 10, 2024) Highlights nature.com/articles/s4158… 🖨️ Original reference: Ralph Stefan Grand et al with Lukas Burger and Dirk Schübeler ✉️ Mol. Cell (Sep 25, 2024) sciencedirect.com/science/articl…

Biggest medical discoveries of the week (🧵) 1/10 Why does caloric restriction boost lifespan? This study of ~1,000 mice finds (surprisingly) it's less to do with lowering fat mass, and more to do with boosting immune function and stress resilience nature.com/articles/s4158…

Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with ... biorxiv.org/cgi/content/sh… #biorxiv_genomic

REVIEW: Interfering with KIR and NKG2A immune checkpoint axes to unleash NK cell immunotherapy doi.org/10.1016/j.beha…

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma dlvr.it/TFLTyy

nature.com/articles/s4158…

📖 New review in Nature Reviews Cancer on how epigenomic heterogeneity drives tumour evolution! We dive into: Check it out if you're into epigenetics, single-cell tech, or the future of cancer therapy! 📖 nature.com/articles/s4156…