🧬 Un “interruptor” para una terapia génica más segura 👩‍🔬👨‍🔬 Investigadores del Cima identifican un #ARN con el que se pueden regular los niveles de un #gen terapéutico en función de la respuesta al tratamiento. #InvestigarParaCurar #ResearchToHeal #RNA cima.cun.es/actualidad/not…

European Commission approves the first CRISPR/Cas9 gene-edited therapy, CASGEVY. It’s a new dawn for treatment of Sickle Cell Disease and Transfusion-Dependent Beta Thalassemia. More healing, less suffering for patients! 🙌 #CRISPR crisprtx.gcs-web.com/news-releases/…

Are all gene types equally targeted in scRNA-seq?? No! The essential and cell-type specific lncRNAs are largely overlooked by standard pipelines. Here, we present ELATUS, a workflow tailored to lncRNA in scRNA-seq Maite Huarte Mikel Hernaez 👇biorxiv.org/content/10.110…

😃 Excited to announce our latest publication in @NAR_Open: "TransCistor"! 🤔Are you curious about your favourite #lncRNA's cis-acting potential? Dive into our study, revealing insights from 628 LOF experiments targeting 402 unique lncRNAs. 🔗academic.oup.com/nar/advance-ar…

Very happy to see our our collaborative work with Faraz K Mardakheh out today. We give you TREX (Targeted RNase H-mediated Extraction of X-linked RBPs), a novel method to identify proteins that can bind to any region of any RNA in living cells. Check Faraz K Mardakheh tutorial for more details👇

PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo.

#ecDNA is a major contributor to #cancer #pathogenesis. Here, Xiaowei Yan, Howard Chang & Mischel Lab provide new insight into the biogenesis + maintenance of ecDNA, & its role in altering gene expression + promoting #tumourheterogeneity. go.nature.com/3InRZk6 pic.x.com/A5YcUXn7hH

👩‍🔬Compartimos este artículo divulgativo de nuestra investigadora Marta Montes sobre la #senescencia celular, el proceso de envejecimiento de las células que hoy se estudia para combatir patologías relacionadas con la #edad. 📰 Rincón del aula SEBBM sebbm.es/rincon-del-aul…

🚨 Bridging RNA Biology and Therapy Symposium!! Join us in beautiful Pamplona, October 9th-10th, with amazing speakers to discuss cutting-edge RNA science and therapies Cima Universidad de Navarra🌟 #RNA #noncodingRNA #RNAtherapy Abstract submission open from May 6th! doctaforum-events.org/2024/rnasympos…

🚨 Paper Alert! 🚨 Does RNA regulation impact the p53 pathway and DNA damage response? We reveal distinct m6A-dependent and independent functions of the YTHDC1 protein. Proud of the work by Daniel Elvira Blázquez Cima Universidad de Navarra, collaboration with Raimondi Ivan NY Genome Center 🔗 Read here 👇

🧬 El cáncer colorrectal es uno de los ➕ difíciles de tratar por su resistencia a las terapias. Para mejorar la eficacia de los tratamientos, con #CaixaImpulse Luisa Statello (Cima Universidad de Navarra) desarrolla una terapia dirigida a moléculas de ARN implicadas en esa resistencia.🎯