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Burkitt lymphoma, Wright-Giemsa stained bone marrow aspirate. Rare cases may present as pure leukemia with peripheral blood and bone marrow involvement. "The cytoplasm is deeply basophilic and usually contains lipid vacuoles"

not something you👀everyday... adrenal gland: metastatic Merkel cell carcinoma (patient had prior history)

56 yo woman inguinal lymph node - nodular LP B cell Ly. Stains here CD20 and OCT2. But is that all? Open the comments for a surprise 🕵🏻

Pathologists! Check out our review, comparing current and prior WHO Classifications and ICC, focusing on mature B, T, NK cell, plasma cell & histiocytic/ dendritic cell neoplasms. rdcu.be/dM98O #lymphoma #WHO

CD45+, CD43+, so could be ALCL, but CD30 was negative. Note the fine chromatin of the neoplastic cells, suggesting blasts. Additional IHC: CD68+, lysosome+, NPM1+. Dx is myeloid sarcoma, NPM1+, c/w NPM1 mutation. #hemepath #heme #myeloid

Triple-Negative Tuesday 🔬 Case of Microglandular Adenosis (MGA) of Breast MGA is a curious lesion of breast that lacks myoepithelial cells but retains basement membrane. MGA is “triple-negative” and can be misdiagnosed as invasive carcinoma. #PathTwitter #PathX #breastpath

If you diagnose a nodal T-cell lymphoma with these features: -Morphology is blastoid -No monotypic pattern of TRBC1 by flow cytometry analysis -No TCR gene rearrangement by PCR Add a marker of cell immaturity like TDT, CD34, CD117 etc, even if the clinical features are not

BM 44 yo male with FUO. Diagnosis? Hint: 🍩

Pathologist! What is your diagnosis for this isolated mediastinal mass in a 28-year-old woman?

TRK Thursday 🔬 Case of Secretory Carcinoma of Breast with TRK Immunohistochemistry TRK immunohistochemistry is a sensitive and specific marker for TRK-related neoplasms, such as secretory carcinoma of breast. Can you name other TRK tumors? #PathTwitter #PathX #breastpath

Interfollicular classic Hodgkin lymphoma. CD30 and PAX5. #hemepath #PathTwitter #pathology

4 cases of ALK+ ALCL showing the variability in morphology. #hemepath #pathtwitter #pathology

🚨 New case report! Despite the ancillary tools we have, there are still gray zone cases straddling the boundary of G3 pancreatic neuroendocrine tumor and neuroendocrine carcinoma. Check out our challenging case: rdcu.be/dTPzN #Pathology #GIPath #PancPath #CaseReport

70s F 4cm neck mass. Dx? #PathX #PathTwitter

Pathologists! Check out our open access review of Splenic B-cell lymphomas at this link: doi.org/10.1111/his.15… #spleen #lymphoma

Pathologists! What is your differential diagnosis for this symptomatic lesion of the spinal cord in a middle-aged female? What immunostains or special studies might help you? Hint: CNS involvement is common, although spinal cord is an unusual site. #HemePath

Pathologists! Here is a classic case of Burkitt lymphoma, EBV+, presenting as a nasopharyngeal mass in a little boy. Fortunately, therapy is good and the prognosis is favorable. #Hemepath #Lymphoma

signing out #GUpath prostate biopsies in 2025 #pathmemes

Pathologists! What do you think of this lymph node from 33 yo male with multifocal lymphadenopathy? What other work up would you do? #hemepath #lymphnodes

I’m genuinely glad the Hempath, WHO, and ICC groups are getting along now. Kissing and making up is great. But here’s a cold, hard truth: I’d bet that in your 7th classification, the vast majority of what you include will be inaccessible to 80% of the world’s population. Let