.IAVI secured a $55 million grant from the Gates Foundation to fund a Phase 2b trial for the TB vaccine candidate MTBVAC. The world needs improved vaccines to control TB, which requires diverse candidates to be tested. iavi.org/news-resources…

I haven't read this yet, but it's intriguing: suggests that Ag85B (and other immunodominant++ Ags??) as the 'control' for vax is bad. Mycobacterium tuberculosis Antigen 85B modifies BCG-induced anti-tuberculosis immunity and favors pathogen survival academic.oup.com/jleukbio/artic…

Proud to share our latest publication in Nature Communications nature.com/articles/s4146… La Jolla Institute Sudha bpeters Alessandro Sette

TAG is proud to be part of IMPAACT4TB consortium that is supporting introduction of first-ever child-friendly rifapentine formulation for TB prevention. The Lancet Infectious Diseases reports on consortium's work to bring this game-changing drug to affected communities: thelancet.com/journals/lanin…

Aging can influence the alveolar lining fluid and promote #Mycobacterium #tuberculosis growth and translocation: mucosalimmunology.org/article/S1933-…

We are at UCT IDM for the TB mini-symposium! Promises to be a good day with great science discussions. Digby Warner @TomScriba South African Tuberculosis Vaccine Initiative SAMRC SU, Faculty of Medicine and Health Sciences Division of Molecular Biology and Human Genetics Dannielle Kenny (Moore) @Carly_Young Dr Wynand Goosen TB Genomics #tuberculosis

Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages | Science Advances science.org/doi/10.1126/sc…

Our lab director is supporting the RareDiseaseGenomicsRSA group. Cupcakes for a good cause. Thank you Shahida Moosa #StopTheGenocide and team for the great work you do. The LoxtonLab supports all the efforts!

At the #SAMRCMeeting the Unit Director Prof Rob Warren provided a glimpse into the innovative work happening at the Centre for #TBResearch during the SAMRC's gathering of intra and extramural research units. The Deputy Director Prof Loxton, is also representing Division of Molecular Biology and Human Genetics!

Just released: TB Treatment Pipeline Report 2023, detailing key updates in TB treatment R&D - including recently wrapped and in-progress treatment-shortening trials, and 22 new or repurposed drugs undergoing clinical trials. Read it here: treatmentactiongroup.org/resources/pipe… #CROI2024

Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual participant data meta-analysis thelancet.com/journals/lanin…

#PLOSPathogens: Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis ... dx.plos.org/10.1371/journa…

This #WorldTBDay, the TB Vax ARM has outlined 3 wins for the field to achieve by 2026 in order to effectively advance TB vaccine R&D and ensure equitable and affordable access this decade. 📋 Read the wins & sign the petition to show your support: bit.ly/Wins4TBVax

#Easter #Easter2024

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits | PNAS pnas.org/doi/abs/10.107…

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination dlvr.it/T4tR9Z

SAMRC launches a documentary titled "Saving Lives: Sisonke”, it chronicles the historic vaccine study rollout in South Africa. The Sisonke project, was an initiative led by Professors Glenda Gray, and Linda-Gail Bekker, CEO of Desmond Tutu Health Foundation More on this: shorturl.at/gjmEL

Elisabeth Bik Elisabeth Bik, expert in scientific integrity: ‘We need to slow down scientific publishing' english.elpais.com/science-tech/2…

🚨 Excited to announce the publication of Sarah Sun's PhD work in Immunity!🚨Key finding: BCG vaccination reprograms the epigenetic landscape of human bone marrow progenitor cells, reshaping innate immune responses. Full study here in open access: authors.elsevier.com/c/1jcFF3qNrUxu…

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