Single-cell and Spatial Omics Reveals Region-Specific Plasticity and Therapeutic Vulnerabilities in Metastatic High-Risk Neuroblastoma biorxiv.org/content/10.110… #biorxiv_cancer

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function cell.com/neuron/fulltex… Neuron

we are getting closer to the new limit

In the latest issue! HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics dlvr.it/TNnXYB

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice nature.com/articles/s4146… via John Lukens

scooby achieves DNA sequence-based single-cell level modeling of RNA-seq coverage and ATAC-seq insertion profiles by adapting a deep learning model that predicts bulk RNA-seq coverage. Johannes Hingerl Laura Martens (@lauradmartens.bsky.social) gagneurlab TU München nature.com/articles/s4159…

🤯 New in nature from MD Anderson Cancer Center colleagues Adam Grippin Steven H. Lin SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade nature.com/articles/s4158…

Cells don’t just exist — they talk, signal, and collaborate. Our work GraphComm is now out in Scientific Reports ! With GraphComm, we’re teaching AI to listen in on this cellular conversation — a step closer to building the virtual cell. 🧬🤖 🧬 GraphComm is a graph-based deep

In this Orli Bahcall commentary, I reflect on an older paper from the Campbell group Wellcome Sanger Institute showing how normal skin is full cancer mutations yet stays healthy to highlight the opportunity to revisit this question using new spatial omics tech: nature.com/articles/s4157…

Insights, opportunities, and challenges provided by large cell atlases🤗 genomebiology.biomedcentral.com/articles/10.11…

Major week for mosquito research 🦟 New Science paper by Yuki Haba and @LindyMcBr on the origin of the London Underground mosquito: science.org/doi/10.1126/sc… Stay tuned - 2 more exciting studies coming this week!

Nadav Shai Lindy McBride Thank you Nadav for sharing our work! Super excited for the upcoming studies 👀

Prof. Eric Topol at Helmholtz Munich: Exploring the Virtual Human 👉 t1p.de/5wthc Prof. Eric Topol, internationally renowned cardiologist, geneticist, and digital medicine expert, visited #HelmholtzMunich for a roundtable on the future of #AI in healthcare. ✨ The

Integrated cell atlas and tumoroids chart #PancreaticCancer therapeutic targets biorxiv.org/content/10.110… Website for pancreatic cancer scRNA seq atlas: cells.ucsc.edu/?ds=pdac-atlas

"Improving long-read somatic structural variant calling with pangenome and de novo personal genome assembly" from Heng Li et al Seemingly big reduction in SV false positives! biorxiv.org/content/10.110…

81 Cell papers over his lifetime. Legend!

Philip Mudd's group (Philip Mudd) has been hard at work bringing TIRTL-seq to WashU. Deep paired sequencing working with massive thanks to Mikhail Pogorelyy and Paul G Thomas. Preprint: biorxiv.org/content/10.110… GPU-optimized pairing algorithm: github.com/pogorely/TIRTL

At the Staatskanzlei Munich for the State Reception celebrating Bavaria’s Excellence Clusters — great to see so much scientific excellence and innovation recognized and supported across disciplines. 🚀🇩🇪 #Wissenschaft #Innovation #Bayern

Daniel Litt A paper by Babai on the topic from 1990. Section 16 is particularly on point. people.cs.uchicago.edu/~laci/papers/e…

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