K-FIT: An accelerated kinetic parameterization algorithm using steady-state fluxomic data biorxiv.org/cgi/content/sh… #bioRxiv

Glycans are the main drivers of inter-individual variability. In this large study on Twins, they contribute to understanding of autoimmune thyroid disease. biorxiv.org/content/10.110…

Incorporating polygenic scores in the twin model to estimate genotype-environment covariance: exploration of statistical power biorxiv.org/content/10.110…

Tons of good ideas and pointers on what AI can do to improve clinical trials, from design to enrollment and monitoring cell.com/trends/pharmac…

Our paper on integrating MR and moloc is now out in Human Molecular Genetics!Thanks Tom Richardson Tom Gaunt and george davey smith for patiently guiding a basic scientist like me through the daunting world of epidemiology. Excited to do more epi work in the future! academic.oup.com/hmg/advance-ar…

Genetic drug target validation using Mendelian randomization dlvr.it/RDvJL5

A strategy to incorporate prior knowledge into correlation network cutoff selection biorxiv.org/content/10.110…

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases biorxiv.org/content/10.110…

Genetic control of the human brain proteome biorxiv.org/content/10.110…

We are hiring a bioinformatics intern (MSc level) to work with us on autoimmune diseases! novartis.com/careers/career…

Latent factor modelling of scRNA-seq data uncovers novel pathways dysregulated in cell subsets of autoimmune disease patients biorxiv.org/content/10.110…

Juan hanging out with the ladz Tim Spector MD (Prof)

#genomics #bioinformatics #machinelearning #biostatistics #drugdiscovery #immunology

Hello Twitter! Looking forward to sharing lots of interesting tweets on systems metabolomics with you. Visit our current website to find out more about our exciting research: metabolomics.helmholtz-muenchen.de

Congrats to Karsten Suhre, Tim Spector MD (Prof) Metabolon, Inc. and collaborators on the publication of their saliva metabolite QTL study: ncbi.nlm.nih.gov/pubmed/31960908 Below is my favorite novel finding (DPYS geen) which I illustrated following their submission to bioRxiv last year.

Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes biorxiv.org/content/10.110…

We are hiring! Check out the position below if you are interested in using bioinformatics to develop novel drugs for autoimmune diseases novartis.com/careers/career…

Interested in using bioinformatics and human genetics to come up with novel treatments for neurological diseases? Apply here: novartis.com/careers/career…

Interested in applying bioinformatics to develop novel drugs for autoimmune diseases? Check out this position in our team Novartis novartis.com/careers/career…

Interested in applying data science to drug discovery? Check out Novartis' innovation postdoc program!