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Very proud of our study in Blood (+cover and editorial) led by @sarahelitzur and @Ruthyshioh describing a novel non-canonical MAPK activation pathway leading to histiocytosis, in patients with H syndrome. From bed to bench and back to bedside. ncbi.nlm.nih.gov/pubmed/37738562

Honored and grateful to work at #NIAID with fantastic mentors @SeretIDirini Christa Zerbe Mihalis Lionakis ... Working to understand the pathogenesis of #HLH in adults/peds to optimize treatments of this complex syndrome. No better time for clin-translational research, lots of work to do!

Fantastic case and discussion, thank you for the invite, always excited to talk about HLH/MAS!

Fantastic piece! Definitely time for action and time for ID to join the immunology revolution, tons of opportunities at NIH/NIAID ID Fellowship, not to mention amazing mentors @SeretIDirini Bethesda ID Fellows Christa Zerbe

You call it healthcare/ your life / your body / your health… Healthcare insurers call it a “medical LOSS ratio”…as in YOUR care is their financial loss…🤬 They care about your premiums. They do not care about you. They care to deny as much as they can of your medical

Fantastic to see this finally out! Fascinating pathophysiology at the intersection of pathogen and host. Grateful to help contribute to a portion of it.

Persons with HIV with low nadir CD4 and/or inflammatory complications are at high risk of clonal hematopoiesis regardless of age that could benefit from risk reduction and potentially targeted immunomodulation JCI insight @SeretIDirini insight.jci.org/articles/view/…

Awesome!! What a great choice, very well-deserved!

Powerhouse of former and current NIH ID Fellows presenting a clinical case for NIAID Grand Rounds! Amazing work all around re: IRIS and Nocardia. Drs. Immel, Epling and Abers. Bethesda ID Fellows @SeretIDirini Joe Rocco @NIAIDTraining

Another NIH Fellow now Assistant Clinical Investigator Joe Rocco given NIAID Grand Rounds on HLH and pathogenesis. Bethesda ID Fellows

Amazing case and great catch! I think in complex adults, we are missing many genetic diagnoses ... lots more to find, great write up!

Awesome story, really amazing clinical translational science, Congrats! Mihalis Lionakis Joseph Pechacek and all

Gratifying to see a trial that I started writing as a 2nd year fellow changing the lives of our patients with #lymphoma! A huge thanks to everyone @NCICCR_Lymphoma at National Cancer Institute and the many others involved in this momentous accomplishment!!!

This was an amazing case to try to figure out ... looks like lymphoma, looks like HLH, severe DRESS is absolutely fascinating and still trying to grasp how HHV6 is involved!

m.youtube.com/watch?v=JJ7vI4… Just dropping this here. Come see what we are all about! Bethesda ID Fellows Rachel Strength @NIAIDTraining Joe Rocco @SeretIDirini Veronique Mihalis Lionakis Tara Palmore

Dr. Lauren Meyer is presenting novel findings from the HLHRUXO trial and a detailed analysis of T cell phenotypes in HLH using single-cell sequencing! #HSGoa2024 #HLH #letsgalkhistiocytosis

Dr. Bethany Verkamp shares novel and significant results on the impact of Emapalumab in treating pediatric HLH! #HSGoa2024 #histiocytosis #HLH #letstalkhistiocytosis

Histiocyte Society #HLH Webinar "Multi-disciplinary Approach to Managing HLH" Headlined by Jessica Manson & Rachel Tattersall (UCL) who've really brought HLH excellences to NHS July 24th, 11AM NY/8AM SF/4PM UK/5PM CET Details and link are forthcoming