Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading!

Great to see that our recent work was highlighted in the Research News Journal of General Physiology !

🧑‍🔬🎙️ Did you know that JGP supports video summaries of your research? When you publish with JGP, you can reach more of your community by submitting a short video! 🎦 See our guidelines: hubs.la/Q03vr0vx0 ▶️ Watch video summaries from our authors: hubs.la/Q03vr6qc0

#CallForPapers on the topic of Society of General Physiologists’s 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” - we welcome submissions on diverse membrane protein families involved in transporting anions 👉 hubs.la/Q039qFSz0

Our July issue is here! hubs.la/Q03vJ9tM0 The cover image highlights the voltage-gated sodium channel NaV1.8 and its targeted drug Journavx, illustrating their role in pain perception and therapeutic intervention. From Wood et al. hubs.la/Q03vJccH0

Single-molecule imaging provides a high spatial resolution of fluorescent ATP binding to myosin within cardiac myofibrils. Pilagov, Steczina, Naim, Kad et al. University of Kent study PKA phosphorylation and a haploinsufficiency-causing mutation from human tissue. hubs.la/Q03w2M9f0

Clerx et al. Uni of Nottingham #WeAreUoN present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. hubs.la/Q03xvdTQ0

Colleen Clancy UC Davis Physiology highlights the comprehensive meta-analysis by Clerx et al. (hubs.la/Q03xvjrh0 ) that challenges long-standing assumptions about data interpretation, data comparison, and electrophysiological data used to develop models. hubs.la/Q03xvkNX0

#CallForPapers 📣 We invite submissions on the topic of Society of General Physiologists’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics!” with Guest Editors Anne Carlson & Zhaozhu Qiu! Learn more: hubs.la/Q039qpPw0

📣#CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology and Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health and Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉hubs.la/Q03y2ggP0

📣#CallForPapers We're accepting submissions on the topic of the Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉hubs.la/Q03y2h0C0

Martin Heiss, Bernhard Flucher et al. unravel molecular mechanisms in a voltage-sensing domain that governs the kinetics and voltage dependence of calcium channel activation. hubs.ly/Q03B7Jh_0 #IonChannels

Martínez-Lázaro, Bartolomé-Martín, Giraldez et al University Of Limerick show that two GRIN2B variants disrupt nanoscale coupling btwn NMDA receptors and BK channels, revealing nanodomain dysfunction as a potential mechanism contributing to GRIN2B-associated pathophysiology hubs.la/Q03Bp-kP0

The Naranjo group show that charybdotoxin binding to Shaker K⁺ channels is temperature-sensitive in high external K⁺ but not in high external Na⁺. Binding of CTX to Shaker appears to be diffusion limited and, counterintuitively, is temperature dependent hubs.la/Q03BNs4c0

📣#CallForPapers Submit your research on the topic of the Electrophysiology & #IonChannel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉hubs.la/Q03y2g4J0

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation, say Martin Heiss, Bernhard Flucher et al. hubs.la/Q03B7FnP0 #IonChannels

Woods, Swank, and Miller UMass Amherst demonstrate that stretch-activated force production is maintained under fatiguing conditions, while calcium-activated force declines in fast-contracting #SkeletalMuscle fibers. hubs.la/Q03C7Hv90

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains, say Rebeca Martínez-Lázaro, David Bartolomé-Martín, Teresa Giraldez et al. Universidad de La Laguna hubs.la/Q03BpVRC0 #Biophysics #Pathophysiology #IonChannels

Frindt, Palmer et al. study the kinetics of processing of the epithelial Na channel (ENaC) in rat kidney. Alterations in levels of aldosterone produced rapid changes in cleaved γENaC and αENaC, with slower changes in full-length forms of the subunits. hubs.la/Q03Cmmv30

📣#CallForPapers Topics of interest include, but are not limited to, #ionchannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 hubs.la/Q03y2dlQ0