Protein structure design is here! Hope our recent work (nature.com/articles/s4158…) on de novo design of protein sensors will be interesting and relevant to others curious in functional protein design.

All atom biomolecular modeling 🤯 Institute for Protein Design science.org/doi/10.1126/sc…

Happy to share that the Ras sensors (Ras-LOCKR-S and Ras-LOCKR-PL) are now on Addgene! addgene.org/browse/article…

Giving a talk at CSHL on my 30th birthday 😬

NCI blog post about my de novo designed Ras biosensors: cancer.gov/research/key-i…

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

The future faculty page of Baker lab postdocs is now online! bakerlab.org/future-faculty/ Please check out the cool things my colleagues and I are doing and plan to do!

Excited to share that my K99 at NCI is awarded! I will continue to build new protein tools to understand the signaling programs enabling Ras drug resistance. And with that, a shameless plug that I’m on the faculty market this Fall 2024 👀.

#NewProfilePic (Hire me please 🥺)

Reason to go to conferences: collect their cute shirts 😂 proteinsociety #PS38

Recently out at Nat Chem Bio! I used my Ras biosensors (Zhang et al Nat Biotech 2024) to profile the activity and environment of Ras at the single-cell level, which unveiled the signaling mechanisms underlying RasG12C inhibitor resistance. nature.com/articles/s4158… Institute for Protein Design

Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. biorxiv.org/content/10.110…

Excited to visit University of Utah! I really appreciate the opportunity to share my recent work Paul Sigala Ben Myers Lab 🙏🏼!

Fantastic first day of science with our Postdoc Rising Stars and amazing keynote by Elizabeth Villa on jumbo phages!@UofUBiochem U of U NUIP Huntsman Cancer Institute University of Utah College of Pharmacy Burroughs Wellcome Fund

This is an honor well deserved! I am always amazed by the sheer ingenuity David and our lab always produces. Congratulations to David! Institute for Protein Design

Just started my BlueSky account: jasonzxzhang.bsky.social Feel free to add me there as well! Will see how this goes 🤔

Excited to share my recent work on designing new Hsp70 activators to regulate condensates, and thus reveal their functions: sciencedirect.com/science/articl… Institute for Protein Design

Says someone who doesn’t get any NIH funding 🙄

Online now! De novo designed Hsp70 activator dissolves intracellular condensates. Check out the study by chemistry laureate @Uwproteindesign David Baker, Jason Zhaoxing Zhang & others in CellChemicalBiology #bps2025 hubs.li/Q036KN030