New paper out in Science Advances! 🚀 We show that embryo implantation is not just biochemical, it’s mechanical! Human and mouse embryos push, pull, and sense their environment in very different ways. 🔗science.org/doi/10.1126/sc…

Tamoxifen and Uterine Cancer Link 💥Tmx-associated ECs show fewer PIK3CA mutations, as tmx itself activates the ER–IGF1R–PI3K pathway in the uterus. 📌An example of therapy-induced carcinogenesis via signaling activation rather than mutagenesis👇 nature.com/articles/s4158…

Congratulations to Yale Genetics faculty Dr. Berna Sozen Berna Sozen and Dr. Steven Reilly Steve Reilly, who have been named 2025 Pew Biomedical Scholars! 🎊🧬🔬medicine.yale.edu/news-article/y… #PewBiomedicalScholars #Genetics

Maternal stress triggers early-life eczema through fetal mast cell programming. nature nature.com/articles/s4158…

Cells prioritize the regulation of cell mass density | Science Advances science.org/doi/10.1126/sc…

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new @nature paper, Miranda Hunter found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Estrogen-regulated renal progenitors determine pregnancy adaptation and preeclampsia | Science science.org/doi/10.1126/sc…

Human brain #Organoid scRNAseq + scATACseq + single-cell transcription factor perturbation (CROP-seq, lentiviral gRNA library for 20 TFs, 3 gRNAs/TF, 1 gRNA detected/cell in >22k cells) in GLI3-HES1 antagonism for dorsoventral patterning in human telencephalon Pando:

Excited to share our new Cell paper! 🌱 We uncover how a single somatic cell can regenerate into a whole plant through somatic embryogenesis. Grateful to collaborators Prof. Yinghua Su, Prof. Xiansheng Zhang & Dr. Keke Xia. 👉 cell.com/cell/fulltext/…

Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins. nature.com/articles/s4158…

Pretty awesome work Pedro Medina & team! Congrats 🫡

Our study is now published online in StemCellReports! We map how blood forms from hemogenic endothelium during iPSC differentiation and identify FGF signaling as a barrier to hematopoiesis. cell.com/stem-cell-repo…

My co-authors and I from Konnikova lab lab are very excited to present our research findings on placental immune cells! I’ll highlight some of our key findings in this thread and you can check out the full results linked below.🔬(1/n) biorxiv.org/content/10.110…

🚨Paper alert 🚨 Check out our latest paper: We identified SPP1 as a key regulator of mesenchymal cell fate. Together with GREM1, SPP1 regulates reciprocal epithelial and mesenchymal PDAC cell fate. 📚Read more about this nature paper below ⬇️: nature.com/articles/s4158…

Our study on fibroblast functional heterogeneity in mammary glands is out in Nature Communications! This tour de force by Jakub Sumbal reveals contractile fibroblasts in TEB niche. Great collaboration Institute of Molecular Genetics Science @ MED MUNI with @slvfre Institut Curie. ➡️rdcu.be/eIIKD

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells go.nature.com/42wdD05

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet (jesse veenvliet @jesseveenvliet.bsky.social) MPI-CBG Dresden Physics of Life Dresden 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️biorxiv.org/content/10.110…

1/ Excited to share our new study with Brumbaugh Lab, now out in Nature Biotechnology! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…

Now out in final form, check out our latest work on theca cell mechanics and compressive stress in ovarian follicles. Led by talented Arikta Biswas, this work will not be possible without the support of collaborators and Mechanobiology Institute. Congrats to team! #ProudPI nature.com/articles/s4146…

Thrilled to share our discovery of the genetic switch that creates a hybrid EMT state in the uterus for the first step in embryo implantstion. A fantastic team work with Mohit Kumar Jolly and Shruti Hansda to discover the teams ICMR-NIRRCH IISc Bangalore nature.com/articles/s4142…